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Pulmonary function and bronchopulmonary dysplasia classification: insights from the Spanish Registry
European journal of pediatrics, 2024-09, Vol.183 (9), p.3757-3766
2024
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Autor(en) / Beteiligte
Titel
Pulmonary function and bronchopulmonary dysplasia classification: insights from the Spanish Registry
Ist Teil von
  • European journal of pediatrics, 2024-09, Vol.183 (9), p.3757-3766
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2024
Quelle
MEDLINE
Beschreibungen/Notizen
  • In 2016, the Spanish Research Group on Bronchopulmonary Dysplasia (BPD) (GEIDIS) established a national registry with participation of 66 hospitals to collect information on clinical characteristics and long-term outcomes of BPD infants into adulthood. The aim of this observational study is to examine forced spirometry data in early childhood and to assess their correlation with the respiratory support required at 36 weeks postmenstrual age (PMA). The study analyzed data from preterm infants with BPD born between January 2016 and December 2017 who underwent forced spirometry at 5–7 years of age. Statistical analyses were conducted to investigate the relationships between spirometry results, perinatal factors, and the required respiratory support at 36 weeks PMA. The study involved 143 patients with a median gestational age (GA) of 27.3 weeks (range 25.7–28.7) and a median weight of 880 g (range 740–1135). Abnormal spirometry results were observed in 39.2% (56) of the patients. Among patients diagnosed with BPD type 3, those requiring over 30% oxygen at 36 weeks PMA exhibited an increased risk of abnormal spirometry results (OR 4.48; 95% CI 1.11–18.13) compared to those requiring positive pressure with less than 30% oxygen. In addition, this subgroup had a higher risk of developing a restrictive-mixed pattern compared to those with BPD type 1 (OR 10.65; 95% CI 2.06–54.98) and BPD type 2 (OR 6.76; 95% CI 1.09–42.06). No significant differences were found in the incidence of an obstructive pattern between BPD types.      Conclusion : The requirement of more than 30% oxygen at 36 weeks PMA serves as a risk indicator for pulmonary function impairment in school-aged children with BPD. These findings suggest persistent airway and parenchymal injury in this specific patient population, and highlight the importance of careful monitoring to evaluate their long-term effects on lung function. What is Known: • Premature patients with bronchopulmonary dysplasia (BPD) may present abnormalities in pulmonary function tests during school age. However, the predictive accuracy of consensus BPD severity classification remains uncertain. What is New: • The requirement of more than 30% oxygen at 36 weeks postmenstrual age (PMA) indicates a potential risk of pulmonary function impairment in school-aged children with BPD. Additionally, a significant correlation has been observed between a restrictive-mixed pattern with exposure to mechanical ventilation and the development of severe forms of BPD.
Sprache
Englisch
Identifikatoren
ISSN: 1432-1076, 0340-6199
eISSN: 1432-1076
DOI: 10.1007/s00431-024-05629-w
Titel-ID: cdi_proquest_miscellaneous_3066793244
Format
–
Schlagworte
Age, Bronchopulmonary Dysplasia - diagnosis, Bronchopulmonary Dysplasia - epidemiology, Bronchopulmonary Dysplasia - physiopathology, Child, Child, Preschool, Children, Classification, Dysplasia, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infants, Long-term effects, Lung - physiopathology, Lung diseases, Male, Mechanical ventilation, Medicine, Medicine & Public Health, Oxygen, Patients, Pediatrics, Registries, Respiratory function, Spain - epidemiology, Spirometry, Statistical analysis

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