Details

Autor(en) / Beteiligte

• Wang, Sheng-Huei
• Teng, Chi-Kang
• Chan, Ming-Cheng
• Yang, Kuang-Yao
• Sheu, Chau-Chyun
• Liang, Shinn-Jye
• Huang, Wei-Hsuan
• Feng, Jia-Yih
• Chen, Chia-Min
• Weng, Zi-Xeng
• Peng, Chung-Kan

Titel

The impact and risk factors for developing pneumogenic bacteremia in carbapenem-resistant Acinetobacter baumannii nosocomial pneumonia in the intensive care unit: A multicenter retrospective study

Ist Teil von

• International journal of infectious diseases, 2024-09, Vol.146, p.107128, Article 107128

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• •Pneumogenic bacteremia increased in-hospital mortality by 22.4% in CRAB pneumonia.•A long ICU stay before CRAB pneumonia was a risk factor for pneumogenic bacteremia.•Long days of mechanical ventilation might be associated with pneumogenic bacteremia. This study analyzed the risk and impact of developing pneumogenic bacteremia in patients with CRAB nosocomial pneumonia in ICU. This is multicenter retrospective study. Clinical outcomes were compared between bacteremia and non-bacteremia group, and the risk factors for mortality and developing pneumogenic CRAB bacteremia were analyzed. After patient recruitment, 164 cases were in the bacteremia group, and 519 cases were in the non-bacteremia group. The bacteremia group had 22.4 percentage of increase in-hospital mortality than the non-bacteremia group (68.3% vs 45.9%, P < 0.001). Multivariate analysis showed bacteremia was an independent risk factor for in-hospital mortality (aHR = 2.399, P < 0.001). A long time-interval between ICU admission and pneumonia onset was an independent risk factor for developing bacteremia (aOR = 1.040, P = < 0.001). Spearman's rank correlation analysis indicated a high correlation between the days from ICU admission to pneumonia onset and the days of ventilator use before pneumonia onset (correlation coefficient (ρ) = 0.777). In patients with CRAB nosocomial pneumonia, bacteremia increased the in-hospital mortality, and a longer interval from ICU admission to pneumonia onset was an independent risk factor for developing bacteremia, which was highly associated with the use of mechanical ventilation. [Display omitted]