Details

Autor(en) / Beteiligte

• Hao, Xiao-Dan
• Liu, Jin-Xiu
• Zhang, Jing-Sai

Titel

Longevity factor FOXO3a: A potential therapeutic target for age-related ocular diseases

Ist Teil von

• Life sciences (1973), 2024-08, Vol.350, p.122769, Article 122769

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• The forkhead box protein O3 (FOXO3a) belongs to the subgroup O of the forkhead transcription factor family and plays an important role in regulating the aging process by participating in the regulation of various life processes, including cell cycle arrest, apoptosis, autophagy, oxidative stress, and DNA repair. The eye is an organ that is affected by aging earlier. However, the functional role and potential clinical applications of FOXO3a in age-related eye diseases have not received widespread attention and lacked comprehensive and clear clarification. In this review, we demonstrated the relationship between FOXO3a and visual system health, summarized the functional roles of FOXO3a in various eye diseases, and potential ocular-related therapies and drugs targeting FOXO3a in visual system diseases through a review and summary of relevant literature. This review indicates that FOXO3a is an important factor in maintaining the normal function of various tissues in the eye, and is closely related to the occurrence and development of ophthalmic-related diseases. Based on its vital role in the normal function of the visual system, FOXO3a has potential clinical application value in related ophthalmic diseases. At present, multiple molecules and drugs targeting FOXO3a have been reported to have the potential for the treatment of related ophthalmic diseases, but further clinical trials are needed. In conclusion, this review can facilitate us to grasp the role of FOXO3a in the visual system and provide new views and bases for the treatment strategy research of age-related eye diseases. [Display omitted] •Structure, functions and regulation of FOXO3a•Functional roles of FOXO3a pathway in age-related ocular diseases•Antioxidant, anti-apoptosis and autophagy-promoting roles of FOXO3a in ocular•FOXO3a inhibits cell proliferation and promotes apoptosis of intraocular tumor cells.•Potential ocular-related therapies and drugs targeting FOXO3a