Details

Autor(en) / Beteiligte

• Martínez-Fleta, Pedro
• Marcos, María Celeste
• Jimenez-Carretero, Daniel
• Galván-Román, José María
• Girón-Moreno, Rosa María
• Calero-García, Ana Adela
• Arcos-García, Ana
• Martín-Gayo, Enrique
• de la Fuente, Hortensia
• Esparcia-Pinedo, Laura
• Aspa, Javier
• Ancochea, Julio
• Alfranca, Arantzazu
• Sánchez-Madrid, Francisco

Titel

Imbalance of SARS-CoV-2-specific CCR6+ and CXCR3+ CD4+ T cells and IFN-γ + CD8+ T cells in patients with Long-COVID

Ist Teil von

• Clinical immunology (Orlando, Fla.), 2024-07, Vol.264, p.110267, Article 110267

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Long-COVID (LC) is characterised by persistent symptoms for at least 3 months after acute infection. A dysregulation of the immune system and a persistent hyperinflammatory state may cause LC. LC patients present differences in activation and exhaustion states of innate and adaptive compartments. Different T CD4+ cell subsets can be identified by differential expression of chemokine receptors (CCR). However, changes in T cells with expression of CCRs such as CCR6 and CXCR3 and their relationship with CD8+ T cells remains unexplored in LC. Here, we performed unsupervised analysis and found CCR6+ CD4+ subpopulations enriched in COVID-19 convalescent individuals upon activation with SARS-CoV-2 peptides. SARS-CoV-2 specific CCR6+ CD4+ are decreased in LC patients, whereas CXCR3+ CCR6- and CCR4+ CCR6- CD4+ T cells are increased. LC patients showed lower IFN-γ-secreting CD8+ T cells after stimulation with SARS-CoV-2 Spike protein. This work underscores the role of CCR6 in the pathophysiology of LC. •Decreased SARS-CoV-2-specific CCR6+ CD4+ cells in patients with long-COVID•Increased SARS-CoV-2 specific CXCR3+ CCR6- and CCR4+ CCR6- CD4 cells in long-COVID•Patients with long-COVID have lower IFN-γ + CD8+ T cells