Details

Autor(en) / Beteiligte

• Wang, Kang-Ling
• Balmforth, Craig
• Meah, Mohammed N.
• Daghem, Marwa
• Moss, Alastair J.
• Tzolos, Evangelos
• Kwiecinski, Jacek
• Molek-Dziadosz, Patrycja
• Craig, Neil
• Bularga, Anda
• Adamson, Philip D.
• Dawson, Dana K.
• Arumugam, Parthiban
• Sabharwal, Nikant K.
• Greenwood, John P.
• Townend, Jonathan N.
• Calvert, Patrick A.
• Rudd, James H.F.
• Verjans, Johan W.
• Berman, Daniel S.
• Slomka, Piotr J.
• Dey, Damini
• Mills, Nicholas L.
• van Beek, Edwin J.R.
• Williams, Michelle C.
• Dweck, Marc R.
• Newby, David E.

Titel

Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction

Ist Teil von

• Journal of the American College of Cardiology, 2024-06, Vol.83 (22), p.2135-2144

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Total coronary atherosclerotic plaque activity across the entire coronary arterial tree is associated with patient-level clinical outcomes. We aimed to investigate whether vessel-level coronary atherosclerotic plaque activity is associated with vessel-level myocardial infarction. In this secondary analysis of an international multicenter study of patients with recent myocardial infarction and multivessel coronary artery disease, we assessed vessel-level coronary atherosclerotic plaque activity using coronary 18F-sodium fluoride positron emission tomography to identify vessel-level myocardial infarction. Increased 18F-sodium fluoride uptake was found in 679 of 2,094 coronary arteries and 414 of 691 patients. Myocardial infarction occurred in 24 (4%) vessels with increased coronary atherosclerotic plaque activity and in 25 (2%) vessels without increased coronary atherosclerotic plaque activity (HR: 2.08; 95% CI: 1.16-3.72; P = 0.013). This association was not demonstrable in those treated with coronary revascularization (HR: 1.02; 95% CI: 0.47-2.25) but was notable in untreated vessels (HR: 3.86; 95% CI: 1.63-9.10; Pinteraction = 0.024). Increased coronary atherosclerotic plaque activity in multiple coronary arteries was associated with heightened patient-level risk of cardiac death or myocardial infarction (HR: 2.43; 95% CI: 1.37-4.30; P = 0.002) as well as first (HR: 2.19; 95% CI: 1.18-4.06; P = 0.013) and total (HR: 2.50; 95% CI: 1.42-4.39; P = 0.002) myocardial infarctions. In patients with recent myocardial infarction and multivessel coronary artery disease, coronary atherosclerotic plaque activity prognosticates individual coronary arteries and patients at risk for myocardial infarction. [Display omitted]