Details

Autor(en) / Beteiligte

• Zhou, Wei
• He, Di Demi
• Zhang, Kaixin
• Liu, Ning
• Li, Ying
• Han, Wenzhao
• Zhou, Weiping
• Li, Mengyao
• Zhang, Siyu
• Huang, Haitao
• Yu, Cong

Titel

A perylene diimide probe for NIR-II fluorescence imaging guided photothermal and type I/type II photodynamic synergistic therapy

Ist Teil von

• Biosensors & bioelectronics, 2024-09, Vol.259, p.116424, Article 116424

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2024

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Phototherapy has garnered significant attention in the past decade. Photothermal and photodynamic synergistic therapy combined with NIR fluorescence imaging has been one of the most attractive treatment options because of the deep tissue penetration, high selectivity and excellent therapeutic effect. Benefiting from the superb photometrics and ease of modification, perylene diimide (PDI) and its derivatives have been employed as sensing probes and therapeutic agents in the biological and biomedical research fields, and exhibiting excellent potential. Herein, we reported the development of a novel organic small-molecule phototherapeutic agent, PDI-TN. The absorption of PDI-TN extends into the NIR region, which provides feasibility for NIR phototherapy. PDI-TN overcomes the traditional Aggregation-Caused Quenching (ACQ) effect and exhibits typical characteristics of Aggregation-Induced Emission (AIE). Subsequently, PDI-TN NPs were obtained by using an amphiphilic triblock copolymer F127 to encapsulate PDI-TN. Interestingly, the PDI-TN NPs not only exhibit satisfactory photothermal effects, but also can generate O2•- and 1O2 through type I and type II pathways, respectively. Additionally, the PDI-TN NPs emit strong fluorescence in the NIR-II region, and show outstanding therapeutic potential for in vivo NIR-II fluorescence imaging. To our knowledge, PDI-TN is the first PDI derivative used for NIR-II fluorescence imaging-guided photodynamic and photothermal synergistic therapy, which suggests excellent potential for future biological/biomedical applications. •A perylene diimide (PDI-TN) AIE probe is developed.•The PDI-TN NPs are prepared that give strong NIR-Ⅱ fluorescence.•The NPs exhibit excellent photothermal effect, and can generate O2.•- and 1O2 through type I and type II pathways.•The NPs can be used as a superb imaging agent for in vivo NIR-II fluorescence imaging.•The NPs can be used for imaging-guided PDT/PTT synergistic therapy.