Details

Autor(en) / Beteiligte

• Wasim, Muhammad
• Rafey, Hafiz Abdul
• Sarwar, Sadia
• Nadeem, Humaira
• Ross, Samir Anis
• Shaheen, Farhat

Titel

GC-MS profiling and biological investigations of Cissampelos pareira L. & Lantana camara L

Ist Teil von

• Natural product research, 2024-05, p.1-7

Ort / Verlag

England

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Taylor & Francis SSH 2021

Beschreibungen/Notizen

• The objectives of the study were to conduct phytochemical screening of crude extracts of L. and L. and assessing their biological potentials against protein kinase enzymes, followed by the evaluation of antioxidant and antimicrobial capacities. The n-hexane (A-І, B-І) and ethyl extracts (A-ІІ, B-ІІ) displayed moderate to good antioxidant activity, while the methanol fractions (A-ІІІ, B-ІІІ) showed significant antioxidant activity. Among all the three crude extracts, the ethyl acetate extract (B-II) of exhibited significant protein kinase inhibitions with remarkable antioxidant potential and was therefore purified through column chromatography. Fraction B-ІІ-2 showed the highest flavonoid contents (735.43), with the most promising protein kinase inhibition exerted by the subtractions B-ІІ-2, B-ІІ-3, B-ІІ-4, and B-ІІ-7. Hence, active fractions were examined through GC-MS for the identification of active constituents, revealing 17 active compounds. In the case of , the ethyl acetate crude extract along with fractions led to the identification of more than thirty compounds, which may be further explored to find a potential lead for drug development.