Details

Autor(en) / Beteiligte

• Hongxian, Deng
• Mengyu, Zhang
• Lin, Xiao
• Huanhuan, Li
• Shiqi, Xu
• Si, Zeng
• Luncai, Luo
• Hezhong, Jiang
• Yan, Tong

Titel

Antibacterial activity of pimaradienoic acid from Eleutherococcus trifoliatus (L.) S. Y. Hu

Ist Teil von

• Natural product research, 2024-05, p.1-6

Ort / Verlag

England

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To investigate the antibacterial activity of pimaradienoic acid, a natural product isolated from . Pimaradienoic acid was purified from and tested against three Gram-positive bacteria. Minimum inhibitory concentrations (MICs) were determined, and bacterial growth curves were measured. Scanning electron microscopy (SEM) was used to observe morphological changes in bacteria after drug treatment. Pimaradienoic acid exhibited concentration-dependent inhibition of the growth of the three bacteria tested. The MIC and bacterial growth dynamics results indicated that pimaradienoic acid had potent antibacterial activity. SEM revealed that pimaradienoic acid disrupted the bacterial membrane, leading to cell death. Pimaradienoic acid has significant antibacterial activity against Gram-positive bacteria, suggesting its potential as a novel antimicrobial agent.