Details

Autor(en) / Beteiligte

• Pons-Fuster, Eduardo
• Bernal, Enrique
• Guillamón, Concepción F
• Gimeno, Lourdes
• Martínez-Sánchez, María V
• Ruiz-Lorente, Inmaculada
• Campillo, José A
• Ceballos, Diana
• Torres, Ana
• Tomás, Cristina
• Muñoz, Ángeles
• Alcaraz, Antonia
• Selma, Pedro
• Ruiz-Nicolas, Carlos
• Muro, Manuel
• Minguela, Alfredo

Titel

HLA-C07 is associated with symptomatic HIV-1-associated neurocognitive disorders (HAND) and immune dysregulation

Ist Teil von

• Infectious diseases (London, England), 2024-10, Vol.56 (10), p.818-829

Ort / Verlag

England

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• HIV-1-associated neurocognitive disorders (HAND) in stable patients undergoing antiretroviral therapy (ART) may result from ongoing immune dysregulation and chronic inflammation. A contributing factor may result from the unstable HLA class I allele, HLA-C*07. To assess the genetic profile of killer-cell immunoglobulin-like receptors (KIR), human leukocyte antigens (HLA), and immune activation or senescence markers and their association with HAND in stable HIV-1 patients receiving ART. An observational cross-sectional study was carried out with 96 patients with asymptomatic or symptomatic HAND. HLA and KIR as well as immune activation/senescence biomarkers in peripheral blood cells were assessed by SSO-Luminex typing and flow cytometry, respectively. HLA-C*07 is associated with symptomatic HAND. The frequency of two copies of HLA-C*07 was higher in patients with symptomatic than with asymptomatic HAND (12.0 vs. 2.2%,  < 0.001). The percentage of senescent CD8 CD28 T-cells was higher in patients with two copies of HLA-C*07 (  < 0.05). In patients with symptomatic HAND, the percentages of non-senescent CD8 CD28 T cells were inversely proportional to the number of copies of the HLA-C*07 (  < 0.05). Patients with symptomatic HAND showed a higher frequency of the homozygotic unstable HLA-C*07 allotype, which could be associated with neurocognitive complications. Two copies of HLA-C*07 were associated with immune senescent T lymphocyte profiles characterized by the loss of CD28 expression.