Details

Autor(en) / Beteiligte

• Wang, Zheng
• Yu, Zhe-Wei
• Zhang, Yi
• Wang, Wen-Hui
• Wu, Xin-Yi
• Liu, Shun-Zhi
• Bin, Yan-Lin
• Cai, Bang-Ping
• Huang, Shi-Yan
• Fang, Mei-Juan
• Qi, Rong
• Li, Ming-Yu
• Qiu, Ying-Kun

Titel

Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara

Ist Teil von

• Journal of natural medicines, 2024-05

Ort / Verlag

Japan

Erscheinungsjahr

2024

Quelle

2022 ECC(Springer)

Beschreibungen/Notizen

• In this study, 14 abietene and pimarene diterpenoids were isolated from the woods of Agathis dammara. Among them, 4 new compounds, dammarone A-C and dammaric acid A (1-4), were firstly reported, respectively. The structure of the new compounds was determined by HR ESI-MS and 1D/2D NMR spectroscopy, and their absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. The hypoglycemic effect of all compounds was evaluated by transgenic zebrafish model, and the structure-activity relationship was discussed. Hinokione (7, HO) has low toxicity and significant hypoglycemic effects on zebrafish, the mechanism is mainly by promoting the differentiation of zebrafish pancreatic endocrine precursor cells (PEP cells) into β cells, thereby promoting the regeneration of pancreatic β cells.