Details

Autor(en) / Beteiligte

• Wang, Yudi
• Zhang, He
• Zhang, Xuehua
• Mu, Peizheng
• Zhao, Leilei
• Qi, Ruomei
• Zhang, Yurui
• Zhu, Xiao
• Dong, Yucui

Titel

The role of IGFBP-3 in tumor development and progression: enlightenment for diagnosis and treatment

Ist Teil von

• Medical oncology (Northwood, London, England), 2024-05, Vol.41 (6), p.141, Article 141

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2024

Quelle

SpringerLink

Beschreibungen/Notizen

• IGFBP-3 is aberrantly expressed in many tumor types, and its serum and tumor tissue levels provide auxiliary information for assessing the degree of tumor malignancy and patient prognosis, making it a potential therapeutic target for human malignancies and conferring it remarkable clinical value for determining patient prognosis. In this review, we provide a comprehensive overview of the aberrant expression, diverse biological effects, and clinical implications of IGFBP-3 in tumors and its role as a potential prognostic marker and therapeutic target for tumors. In addition, we summarize the signaling pathways through which IGFBP-3 exerts its effects. IGFBP-3 comprises an N-terminal, an intermediate region, and a C-terminal structural domain, each exerting different biological effects in several tumor cell types in an IGF-dependent/non-independent manner. IGFBP-3 shares an intricate relationship with the tumor microenvironment, thereby affecting tumor growth. Overall, IGFBP-3 is an essential regulatory factor that mediates tumor occurrence and progression. Gaining deeper insights into the fundamental characteristics of IGFBP-3 and its role in various tumor types will provide new perspectives and allow for the development of novel strategies for cancer diagnosis, treatment, and prognostic evaluation.