Details

Autor(en) / Beteiligte

• Trullàs, Joan Carles
• Peláez, Ana Isabel
• Blázquez, Julio
• Sánchez-Biosca, Anna
• López-Reborio, Manuel Lorenzo
• Salamanca-Bautista, Prado
• Fernández-Rodríguez, José María
• Vázquez-Ronda, Miguel Ángel
• Dávila-Ramos, Melitón Francisco
• Mendoza-Ruiz-De-Zuazu, Humberto
• Morales-Rull, José Luís
• Olmedo-Llanes, Jesús
• Llàcer, Pau
• Conde-Martel, Alicia
• Salamanca Bautista, Prado
• Ruiz-Hueso, Rocío
• Domingo, Soraya
• Núñez, Mª Victoria
• Olmedo, Jesús
• Vázquez, Carmen
• Bosco-López, Juan
• Peinado, Alejandro
• Montes, Juan Antonio
• Díez-Manglano, Jesús
• Martínez-Rodés, Pablo
• Garcés, Vanesa
• Rubio, Jorge
• Fernández Rodríguez, José M.
• Argüelles-Curto, Adrián
• Torrallardona-Murphy, Orla
• Gavà-Manso, Meritxell
• García, José Mª
• González, Sonia
• Dávila, Melitón F.
• Hernández, Rubén
• Gudiño, Diego José
• Mendoza, Humberto
• Carrera, Margarita
• Epelde, Francisco
• Becerra, Raquel
• Gil, Mercè
• Massi, Paulina Ivanova
• Chivite, David
• Formiga, Francesc
• Núñez, Raquel
• Pacho, Cristina
• Contra, Anna
• Ceresuela, Luis
• Morales, José Luís
• Pla, Xavi
• López, Gabriel
• López-Reboiro, Manuel-Lorenzo
• Castro, José López
• Asenjo, María
• de Peralta, Paula
• Manzano, Luis
• Ruiz-Ortega, Raúl Antonio
• Vázquez, Miguel Ángel
• Soler, Llanos
• Mesado, Daniel
• Casado, Jesús
• Abad, Daniel
• Peláez Ballesta, Ana Isabel
• Morcillo-Rodríguez, Elena

Titel

The significance of metabolic alkalosis on acute decompensated heart failure: the ALCALOTIC study

Ist Teil von

• Clinical research in cardiology, 2024-08, Vol.113 (8), p.1251-1262

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Aims To determine the prevalence and the impact on prognosis of metabolic alkalosis (MA) in patients admitted for acute heart failure (AHF). Methods and results The ALCALOTIC is a multicenter, observational cohort study that prospectively included patients admitted for AHF. Patients were classified into four groups according to their acid–base status on admission: acidosis, MA, respiratory alkalosis, and normal pH (reference group for comparison). Primary endpoint was all-cause in-hospital mortality, and secondary endpoints included 30/90-day all-cause mortality, all-cause readmission, and readmission for HF. Associations between endpoints and acid–base alterations were estimated in a multivariate Cox regression model including sex, age, comorbidities, and Barthel index and expressed as hazard ratio (HR) with 95% confidence interval (95% CI). Six hundred sixty-five patients were included (84 years and 57% women), and 40% had acid–base alterations on admission: 188 (28%) acidosis and 78 (12%) alkalosis. The prevalence (95% CI) of MA was 9% (6.8–11.2%). Patients with MA were more women; had fewer comorbidities, better renal function, and higher left ventricle ejection fraction values; and received more treatment with oral acetazolamide during hospitalization and at discharge. MA was not associated with a higher risk of in-hospital mortality and 30/90-day all-cause mortality or readmissions but was associated with a significant increase in readmissions for HF at 30 and 90 days (adjusted HR [95% CI] 3.294 [1.397–7.767], p  = 0.006 and 2.314 [1.075–4.978], p  = 0.032). Conclusion The prevalence of MA in patients admitted for AHF was 9%, and its presence was associated with more readmissions for HF but not with all-cause mortality. Graphical abstract