Details

Autor(en) / Beteiligte

• Amar, David
• Gay, Nicole R
• Jimenez-Morales, David
• Jean Beltran, Pierre M
• Ramaker, Megan E
• Raja, Archana Natarajan
• Zhao, Bingqing
• Sun, Yifei
• Marwaha, Shruti
• Gaul, David A
• Hershman, Steven G
• Ferrasse, Alexis
• Xia, Ashley
• Lanza, Ian
• Fernández, Facundo M
• Montgomery, Stephen B
• Hevener, Andrea L
• Ashley, Euan A
• Walsh, Martin J
• Sparks, Lauren M
• Burant, Charles F
• Rector, R Scott
• Thyfault, John
• Wheeler, Matthew T
• Goodpaster, Bret H
• Coen, Paul M
• Schenk, Simon
• Bodine, Sue C
• Lindholm, Malene E

Titel

The mitochondrial multi-omic response to exercise training across rat tissues

Ist Teil von

• Cell metabolism, 2024-04

Ort / Verlag

United States

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative proteins increased in striated muscles. Exercise-upregulated networks were downregulated in human diabetes and cirrhosis. Knockdown of the central network protein 17-beta-hydroxysteroid dehydrogenase 10 (HSD17B10) elevated oxygen consumption, indicative of metabolic stress. We provide a multi-omic, multi-tissue, temporal atlas of the mitochondrial response to exercise training and identify candidates linked to mitochondrial dysfunction.