Details

Autor(en) / Beteiligte

• Hillestad, Eline Margrete Randulff
• Steinsvik, Elisabeth Kjelsvik
• Teige, Erica Sande
• Rasmussen, Stella Hellgren
• Brønstad, Ingeborg
• Lundervold, Arvid
• Hausken, Trygve
• Hanevik, Kurt
• Lied, Gülen Arslan
• Berentsen, Birgitte

Titel

Nutritional safety and status following a 12‐week strict low FODMAP diet in patients with irritable bowel syndrome

Ist Teil von

• Neurogastroenterology and motility, 2024-07, Vol.36 (7), p.e14814-n/a

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background A low FODMAP diet (LFD) is an established dietary treatment for patients with irritable bowel syndrome (IBS). However, knowledge on the extended effects of the restriction phase regarding nutrient intake, symptom severity, and quality of life (QoL) is sparse. Therefore, our objectives were to evaluate the safety of a dietitian‐led 12‐week strict LFD on measures of blood biochemistry, nutritional status, symptom severity, and QoL. Methods In this open‐label dietitian‐led 12‐week strict LFD intervention for IBS patients with predominantly diarrhea or mixed stool pattern (IBS‐D/−M), we collected data on diet intake (3‐day dietary record), overnight fasting routine blood samples, body weight, IBS symptoms (IBS Severity Scoring System (IBS‐SSS)), and IBS‐related QoL (IBS‐QoL) at baseline and after 12 weeks. Key Results Thirty‐six participants completed the 12‐week follow‐up (mean age: 37 years, 67% women, IBS‐SSS: 242 (101)). All blood parameters measured were within established reference values at both time points. We found no change in intake of macro‐ or micronutrients, but several micronutrients were below the recommendations both before and after 12 weeks. BMI slightly decreased, primarily driven by participants with BMI >25 (p < 0.005). QoL improved among most subdomains (p ≤ 0.002), except food avoidance and social reaction. Conclusion An extended dietitian‐guided LFD (12 weeks) is not inferior to the participants' baseline diet, since no clinically meaningful changes in nutritionally related blood samples and no changes in macro‐ or micronutrient intake were observed. However, the intake of several nutrients was below the recommendations at both time points indicating low diet quality. Thirty‐six patients with IBS‐D/−M completed a 12‐week low FODMAP diet intervention guided by a registered dietitian. We observed no changes in blood parameters and in intake of micro‐ and macronutrients, but we saw significant improvements in both IBS symptoms and quality of life.