Details

Autor(en) / Beteiligte

• Bachmann, Katherine N.
• Ceddia, Ryan P.
• Gupta, Deepak K.
• Collins, Sheila
• Wang, Thomas J.

Titel

Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B‐type natriuretic peptide hormone: Results from a randomized controlled crossover study

Ist Teil von

• Diabetes, obesity & metabolism, 2024-08, Vol.26 (8), p.3458-3461

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2024

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Obesity is associated with an increased risk of cardiovascular and metabolic diseases. Despite surgical and pharmacological approaches to reduce weight, limitations due to contraindications, adverse effects, and lack of durable efficacy necessitate additional strategies to treat obesity and its related cardiometabolic complications. Animal models and human genetic studies suggest that the natriuretic peptide (NP) hormone system has a protective role against obesity and cardiometabolic risk. For example, in vitro studies with human adipocytes show that NPs can activate a ‘thermogenic’ programme and increase cell respiration,1 and in vivo mouse studies have shown that administration of B-type natriuretic peptide (BNP) increases thermogenic gene expression in brown and white adipose tissue (a process called ‘browning’ or ‘beiging’ of white fat),2-4 resulting in increased energy expenditure and reduced fat accumulation. While studies have established that infusion of BNP into humans induces adipocyte lipolysis in vivo,5, 6 it has not been previously reported whether administration of exogenous NPs also promotes ‘beiging’ of adipose tissue in humans. This might be a strategy for reducing obesity and cardiometabolic risk in humans, targeting a novel mechanism distinct from current US Food and Drug Administration (FDA)-approved therapies. We hypothesized that intravenous BNP administration in humans activates adipocyte signalling mechanisms that promote thermogenesis. Following an acute infusion of BNP, we measured adipose tissue gene expression of uncoupling protein 1 (UCP1), a protein exclusively expressed in brown and beige adipocytes and an indicator of adipocyte thermogenic programme induction.