Details

Autor(en) / Beteiligte

• Mengesha, Mengistu G.
• Rajasekaran, Shanmuganathan
• Ramachandran, Karthik
• Sengodan, Vetrivel Chezian
• Yasin, Nor Faissal
• Williams, Luke Michael
• Laubscher, Maritz
• Watanabe, Kota
• Dastagir, O.Z.M.
• Akinmade, Akinola
• Fisseha, Hizkyas K.
• Aziz, Amer
• Yurac, Ratko
• Gebrehana, Ephrem
• AlSaifi, Mohammed
• Pathinathan, Kalaventhan
• Sudhir, G.
• Shokri, Amran Ahmed
• Chan Kim, Yong
• Jonayed, Sharif Ahmed
• Kido, Gonzalo R.
• Ignacio, Jose Manuel
• Mohammed, Matiyas Seid
• Abubakar, Kabir
• Hakim, Jonaed
• Duwal Shrestha, Sailendra Kumar
• Al Mamun Choudhury, Abdullah
• Diallo, Malick
• Molina, Marcelo
• Patwardhan, Sandeep
• Hai, Yong
• Ramat, Ali M.
• Kawai, Momotaro
• Cho, Jae Hwan
• Shah Kalawar, Rosan Prasad
• Choi, Sung-Woo
• Zarate-Kalfopulos, Baron
• Guiroy, Alfredo
• Astur, Nelson
• Buunaaim, AlexisD.B.
• Human, Anton L.
• Zaman, Atiq Uz

Titel

Orthopedic postoperative infection profile and antibiotic sensitivity of 2038 patients across 24 countries – Call for region and institution specific surgical antimicrobial prophylaxis

Ist Teil von

• Journal of orthopaedics, 2024-09, Vol.55, p.97-104

Ort / Verlag

India: Elsevier B.V

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Improper utilization of surgical antimicrobial prophylaxis frequently leads to increased risks of morbidity and mortality.This study aims to understand the common causative organism of postoperative orthopedic infection and document the surgical antimicrobial prophylaxis protocol across various institutions in to order to strengthen surgical antimicrobial prophylaxis practice and provide higher-quality surgical care. This multicentric multinational retrospective study, includes 24 countries from five different regions (Asia Pacific, South Eastern Africa, Western Africa, Latin America, and Middle East). Patients who developed orthopedic surgical site infection between January 2021 and December 2022 were included. Demographic details, bacterial profile of surgical site infection, and antibiotic sensitivity pattern were documented. 2038 patients from 24 countries were included. Among them 69.7 % were male patients and 64.1 % were between 20 and 60 years. 70.3 % patients underwent trauma surgery and instrumentation was used in 93.5 %. Ceftriaxone was the most common preferred in 53.4 %. Early SSI was seen in 55.2 % and deep SSI in 59.7 %. Western Africa (76 %) and Asia-Pacific (52.8 %) reported a higher number of gram-negative infections whereas gram-positive organisms were predominant in other regions. Most common gram positive organism was Staphylococcus aureus (35 %) and gram-negative was Klebsiella (17.2 %). Majority of the organisms showed variable sensitivity to broad-spectrum antibiotics. Our study strongly proves that every institution has to analyse their surgical site infection microbiological profile and antibiotic sensitivity of the organisms and plan their surgical antimicrobial prophylaxis accordingly. This will help to decrease the rate of surgical site infection, prevent the emergence of multidrug resistance and reduce the economic burden of treatment. •The incidence and prevalence of surgical site infection (SSI) differs from each region which depends on the bacterial flora in the specific region.•Hence appropriate selection, timing, and duration of surgical antibiotic prophylaxis (SAP) is mandatory to prevent the risk of postoperative surgical site infection and emergence of antibiotic resistance.•Hence institution specific SAP must be planned according to the microbiological profile and antibiotic sensitivity of the organisms.