Details

Autor(en) / Beteiligte

• Chen, Mengyao
• Tong, Xiaohan
• Sun, Yanting
• Dong, Chunyan
• Li, Chen
• Wang, Chunhui
• Zhang, Minyi
• Wen, Yixuan
• Ye, Pinting
• Li, Ruihao
• Wan, Jie
• Liang, Shujing
• Shi, Shuo

Titel

A ferroptosis amplifier based on triple-enhanced lipid peroxides accumulation strategy for effective pancreatic cancer therapy

Ist Teil von

• Biomaterials, 2024-09, Vol.309, p.122574, Article 122574

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• As an iron dependent regulatory cell death process driven by excessive lipid peroxides (LPO), ferroptosis is recognized as a powerful weapon for pancreatic cancer (PC) therapy. However, the tumor microenvironment (TME) with hypoxia and elevated glutathione (GSH) expression not only inhibits LPO production, but also induces glutathione peroxidase 4 (GPX4) mediated LPO clearance, which greatly compromise the therapeutic outcomes of ferroptosis. To address these issues, herein, a novel triple-enhanced ferroptosis amplifier (denoted as Zal@HM-PTBC) is rationally designed. After intravenous injection, the overexpressed H2O2/GSH in TME induces the collapse of Zal@HM-PTBC and triggers the production of oxygen and reactive oxygen species (ROS), which synergistically amplify the degree of lipid peroxidation (broaden sources). Concurrently, GSH consumption because of the degradation of the hollow manganese dioxide (HM) significantly weakens the activity of GPX4, resulting in a decrease in LPO clearance (reduce expenditure). Moreover, the loading and site-directed release of zalcitabine further promotes autophagy-dependent LPO accumulation (enhance effectiveness). Both in vitro and in vivo results validated that the ferroptosis amplifier demonstrated superior specificity and favorable therapeutic responses. Overall, this triple-enhanced LPO accumulation strategy demonstrates the ability to facilitate the efficacy of ferroptosis, injecting vigorous vitality into the treatment of PC. [Display omitted] •Zal@HM-PTBC was designed to facilitate ferroptosis by triple-enhanced LPO accumulation strategy.•TME induced the collapse of Zal@HM-PTBC and triggered the production of O2/ROS , which synergistically amplify LPO level.•The degradation of Zal@HM-PTBC consumed GSH in TME and attenuated "detoxification effect" on LPO by inactivating of GPX4.•The release of zalcitabine effectively led to autophagy dependent LPO accumulation.