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Courtship suppression is a behavioral adaptation of the fruit fly. When majority of the females in a fly population are fertilized and non-receptive for mating, a male, after a series of failed attempts, decreases its courtship activity towards all females, saving its energy and reproductive resources. The time of courtship decrease depends on both duration of unsuccessful courtship and genetically determined features of the male nervous system. Thereby, courtship suppression paradigm can be used for studying molecular mechanisms of learning and memory. p-Cofilin, a component of the actin remodeling signaling cascade and product of LIM-kinase 1 (LIMK1), regulates
Drosophila melanogaster
forgetting in olfactory learning paradigm. Previously, we have shown that
limk1
suppression in the specific types of nervous cells differently affects fly courtship memory. Here, we used Gal4 > UAS system to induce
limk1
overexpression in the same types of neurons.
limk1
activation in the mushroom body, glia, and
fruitless
neurons decreased learning index compared to the control strain or the strain with
limk1
knockdown. In cholinergic and dopaminergic/serotoninergic neurons, both overexpression and knockdown of
limk1
impaired
Drosophila
short-term memory. Thus, proper balance of the
limk1
activity is crucial for normal cognitive activity of the fruit fly.