Details

Autor(en) / Beteiligte

• Tian, Niu
• Kobau, Rosemarie
• Friedman, Daniel
• Liu, Yong
• Eke, Paul I.
• Greenlund, Kurt J.

Titel

Mortality and mortality disparities among people with epilepsy in the United States, 2011–2021

Ist Teil von

• Epilepsy & behavior, 2024-06, Vol.155, p.109770, Article 109770

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• •43,231 U.S. deaths listed epilepsy as a cause of death during 2011–2021.•39% listed epilepsy as the underlying and 61% as a contributing cause of death.•Age-adjusted epilepsy mortality rates significantly increased during 2011–2021.•Epilepsy mortality rates differed by age, sex, and racial/ethnic subgroups.•Epilepsy mortality rates also differed by geographic region and urban-rural status. Studies on epilepsy mortality in the United States are limited. We used the National Vital Statistics System Multiple Cause of Death data to investigate mortality rates and trends during 2011–2021 for epilepsy (defined by the International Classification of Diseases, 10th Revision, codes G40.0–G40.9) as an underlying, contributing, or any cause of death (i.e., either an underlying or contributing cause) for U.S. residents. We also examined epilepsy as an underlying or contributing cause of death by selected sociodemographic characteristics to assess mortality rate changes and disparities in subpopulations. During 2011–2021, the overall age-standardized mortality rates for epilepsy as an underlying (39 % of all deaths) or contributing (61 % of all deaths) cause of death increased 83.6 % (from 2.9 per million to 6.4 per million population) as underlying cause and 144.1 % (from 3.3 per million to 11.0 per million population) as contributing cause (P < 0.001 for both based on annual percent changes). Compared to 2011–2015, in 2016–2020 mortality rates with epilepsy as an underlying or contributing cause of death were higher overall and in nearly all subgroups. Overall, mortality rates with epilepsy as an underlying or contributing cause of death were higher in older age groups, among males than females, among non-Hispanic Black or non-Hispanic American Indian/Alaska Native persons than non-Hispanic White persons, among those living in the West and Midwest than those living in the Northeast, and in nonmetro counties compared to urban regions. Results identify priority subgroups for intervention to reduce mortality in people with epilepsy and eliminate mortality disparity.