Details

Autor(en) / Beteiligte

• Huang, Xiang
• Zhou, Jing
• Pei, Shu-Chen
• Cui, Hai-Lei

Titel

TBHP/Et3N‑Promoted Chemoselective Formylation and Peroxidation of Pyrrolo[2,1‑a]isoquinolines

Ist Teil von

• Journal of organic chemistry, 2024-05, Vol.89 (9), p.6353-6363

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient formylation of pyrrolo­[2,1-a]­isoquinoline derivatives has been reached by the use of TBHP (tBuOOH) and Et3N as the mediator. In this strategy, CHO and CDO can be readily incorporated into heteroarenes by the utilization of CHCl3 and CDCl3 as the carbonyl sources. Interestingly, a solvent-controlled chemoselectivity was observed. The use of PhCl as a solvent resulted in dearomatization and peroxidation of pyrrolo­[2,1-a]­isoquinolines, delivering functionalized peroxides in 53–64% yields.