Details

Autor(en) / Beteiligte

• Ibrahim, Daniel M

Titel

Enhancer contacts during embryonic development show diverse interaction modes and modest yet significant increases upon gene activation

Ist Teil von

• Nature genetics, 2024-04, Vol.56 (4), p.558-560

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• [...]most high-resolution experiments have been performed only on frequently used cell types that rarely include those relevant for well-characterized developmental enhancers that for many years have served as workhorse for understanding gene regulatory elements. Similar to the Drosophila study1, this systematic approach provides data for a more comprehensive view and generalized conclusions on enhancer-promoter looping during developmental gene activation, confirming that the nearest promoters are frequently bypassed and that active enhancers contact each other in clusters. [...]the average increase between 'active/inactive' interaction is only around 1.5-fold. Albeit modest, the increase can have a notable effect on the transcription of target genes, consistent with the results of a recent study on an engineered model locus in mouse embryonic stem cells that showed a positive, but non-linear relationship between enhancer-promoter proximity and transcriptional output14.