Details

Autor(en) / Beteiligte

• Palassini, Elena
• Baldi, Giacomo Giulio
• Sulfaro, Sara
• Barisella, Marta
• Bianchi, Giuseppe
• Campanacci, Domenico
• Fiore, Marco
• Gambarotti, Marco
• Gennaro, Massimiliano
• Morosi, Carlo
• Navarria, Federico
• Palmerini, Emanuela
• Sangalli, Claudia
• Sbaraglia, Marta
• Trama, Annalisa
• Asaftei, Sebastian
• Badalamenti, Giuseppe
• Bertulli, Rossella
• Bertuzzi, Alexia Francesca
• Biagini, Roberto
• Bonadonna, Angela
• Brunello, Antonella
• Callegaro, Dario
• Cananzi, Ferdinando
• Cianchetti, Marco
• Collini, Paola
• Comandini, Danila
• Curcio, Annalisa
• D'Ambrosio, Lorenzo
• De Pas, Tommaso
• Dei Tos, Angelo Paolo
• Ferraresi, Virginia
• Ferrari, Andrea
• Franchi, Alessandro
• Frezza, Anna Maria
• Fumagalli, Elena
• Ghilli, Matteo
• Greto, Daniela
• Grignani, Giovanni
• Guida, Michele
• ibrahim, Toni
• Krengli, Marco
• Luksch, Roberto
• Marrari, Andrea
• Mastore, Marinella
• Merlini, Alessandra
• Milano, Giuseppe Maria
• Navarria, Piera
• Pantaleo, Maria Abbondanza
• Parafioriti, Antonina
• Pellegrini, Ilaria
• Pennacchioli, Elisabetta
• Rastrelli, Marco
• Setola, Elisabetta
• Tafuto, Salvatore
• Turano, Salvatore
• Valeri, Sergio
• Vincenzi, Bruno
• Vitolo, Viviana
• Ivanescu, Andrei
• Paloschi, Fiammetta
• Casali, Paolo Giovanni
• Gronchi, Alessandro
• Stacchiotti, Silvia

Titel

Clinical recommendations for treatment of localized angiosarcoma: A consensus paper by the Italian Sarcoma Group

Ist Teil von

• Cancer treatment reviews, 2024-05, Vol.126, p.102722-102722, Article 102722

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Angiosarcoma presents unique challenges in clinical management of localized disease, due to its rarity and aggressiveness.•Dedicated clinical recommendations for angiosarcoma are currently lacking despite the applicability of ESMO guidelines.•The Italian Sarcoma Group, together with patient’s advocates from “Sofia nel Cuore Onlus”, convened to develop specific recommendations, aiming to standardize and harmonize clinical practices for localized angiosarcoma management. Angiosarcoma (AS) represents a rare and aggressive vascular sarcoma, posing distinct challenges in clinical management compared to other sarcomas. While the current European Society of Medical Oncology (ESMO) clinical practice guidelines for sarcoma treatment are applicable to AS, its unique aggressiveness and diverse tumor presentations necessitate dedicated and detailed clinical recommendations, which are currently lacking. Notably, considerations regarding surgical extent, radiation therapy (RT), and neoadjuvant/adjuvant chemotherapy vary significantly in localized disease, depending on each different site of onset. Indeed, AS are one of the sarcoma types most sensitive to cytotoxic chemotherapy. Despite this, uncertainties persist regarding optimal management across different clinical presentations, highlighting the need for further investigation through clinical trials. The Italian Sarcoma Group (ISG) organized a consensus meeting on April 1st, 2023, in Castel San Pietro, Italy, bringing together Italian sarcoma experts from several disciplines and patient representatives from “Sofia nel Cuore Onlus” and the ISG patient advocacy working group. The objective was to develop specific clinical recommendations for managing localized AS within the existing framework of sarcoma clinical practice guidelines, accounting for potential practice variations among ISG institutions. The aim was to try to standardize and harmonize clinical practices, or at least highlight the open questions in the local management of the disease, to define the best evidence-based practice for the optimal approach of localized AS and generate the recommendations presented herein.