Details

Autor(en) / Beteiligte

• Koren, Johannes
• Lang, Clemens
• Gritsch, Gerhard
• Mayer, Lisa
• Hartmann, Manfred
• Hafner, Sebastian
• Kluge, Tilmann
• Baumgartner, Christoph

Titel

Idiopathic generalized epilepsies in the epilepsy monitoring unit: Systematic quantification of focal EEG and semiological signs

Ist Teil von

• Clinical neurophysiology, 2024-06, Vol.162, p.82-90

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• •Automated EEG software detected focal IEDs during long-term video EEG monitoring in all included patients with IGE (n = 32).•Almost a quarter of all detected IEDs showed a negative focal maximum.•Focal seizure symptoms were seen in three-quarter of IGE patients in our study. Focal seizure symptoms (FSS) and focal interictal epileptiform discharges (IEDs) are common in patients with idiopathic generalized epilepsies (IGEs), but dedicated studies systematically quantifying them both are lacking. We used automatic IED detection and localization algorithms and correlated these EEG findings with clinical FSS for the first time in IGE patients. 32 patients with IGEs undergoing long-term video EEG monitoring were systematically analyzed regarding focal vs. generalized IEDs using automatic IED detection and localization algorithms. Quantitative EEG findings were correlated with FSS. We observed FSS in 75% of patients, without significant differences between IGE subgroups. Mostly varying/shifting lateralizations of FSS across successive recorded seizures were seen. We detected a total of 81,949 IEDs, whereof 19,513 IEDs were focal (23.8%). Focal IEDs occurred in all patients (median 13% focal IEDs per patient, range 1.1 – 51.1%). Focal IED lateralization and localization predominance had no significant effect on FSS. All included patients with IGE showed focal IEDs and three-quarter had focal seizure symptoms irrespective of the specific IGE subgroup. Focal IED localization had no significant effect on lateralization and localization of FSS. Our findings may facilitate diagnostic and treatment decisions in patients with suspected IGE and focal signs.