British journal of haematology, 2024-05, Vol.204 (5), p.1862-1871
2024
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- Autor(en) / Beteiligte
- Titel
- Peripheral T‐cell lymphomas expressing CD30 and CD15 expand the spectrum of anaplastic large cell lymphoma, ALK‐negative
- Ist Teil von
- British journal of haematology, 2024-05, Vol.204 (5), p.1862-1871
- Ort / Verlag
- England: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2024
- Quelle
- Wiley Blackwell Single Titles
- Beschreibungen/Notizen
- Summary Peripheral T‐cell lymphomas (PTCL) are morphologically and biologically heterogeneous and a subset expresses CD30, including anaplastic large cell lymphomas (ALCL) and a minority of PTCL, not otherwise specified (PTCL, NOS). ALCL with ALK translocations (ALCL, ALK+) are readily identified by routine diagnostic methods, but differentiating ALCL without ALK translocation (ALCL, ALK−) and PTCL, NOS expressing CD30 (PTCL CD30+) can be challenging. Furthermore, rare PTCL co‐express CD30 and CD15 (PTCL CD30+CD15+); some resemble ALCL, ALK− while others resemble classic Hodgkin lymphoma. To explore the relationship between PTCL CD30+CD15+ and ALCL, ALK−, we analysed 19 cases of PTCL with CD30 expression, previously diagnosed as ALCL, ALK− (nine cases) and PTCL CD30+CD15+ (10 cases) for DUSP22/IRF4 rearrangements, coding RNA expression and selected transcriptome analysis using the NanoString nCounter gene expression analysis platform. Unsupervised clustering showed no clear segregation between ALCL, ALK− and PTCL CD30+CD15+. Three cases previously classified as PTCL CD30+CD15+ showed DUSP22/IRF4 rearrangements, favouring a diagnosis of ALCL, ALK−. Our results suggest that cases previously designated PTCL CD30+CD15+, likely fall within the spectrum of ALCL, ALK−; additionally, a subset of ALCL, ALK− with DUSP22/IRF4 rearrangement expresses CD15, consistent with previous reports and expands the immunophenotypic spectrum of this lymphoma subgroup. Peripheral T‐cell lymphomas expressing diffuse CD30 and variable CD15 share genomic features with anaplastic large cell lymphoma, ALK−. A subset of these cases shows DUSP22 rearrangements. Cases initially described as PTCL with CD30 and CD15 expression are best classified as anaplastic large cell lymphoma, ALK−.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-1048, 1365-2141eISSN: 1365-2141DOI: 10.1111/bjh.19442Titel-ID: cdi_proquest_miscellaneous_3038435270
- Format
- –
- Schlagworte
- Adult, Aged, ALK‐negative, Anaplastic large-cell lymphoma, Anaplastic Lymphoma Kinase - genetics, Anaplastic Lymphoma Kinase - metabolism, CD15, CD30, CD30 antigen, Dual-Specificity Phosphatases - genetics, Female, Gene expression, Gene Rearrangement, Hodgkin's lymphoma, Humans, Interferon regulatory factor 4, Interferon Regulatory Factors - genetics, Interferon Regulatory Factors - metabolism, Ki-1 Antigen - analysis, Ki-1 Antigen - genetics, Ki-1 Antigen - metabolism, Lewis X Antigen - analysis, Lewis X Antigen - metabolism, Lymphoma, Lymphoma, Large-Cell, Anaplastic - diagnosis, Lymphoma, Large-Cell, Anaplastic - genetics, Lymphoma, Large-Cell, Anaplastic - pathology, Lymphoma, T-Cell, Peripheral - diagnosis, Lymphoma, T-Cell, Peripheral - genetics, Lymphoma, T-Cell, Peripheral - metabolism, Lymphoma, T-Cell, Peripheral - pathology, Male, Middle Aged, Mitogen-Activated Protein Kinase Phosphatases - genetics, peripheral T‐cell lymphoma, Transcriptomes, Translocation, Young Adult