Details

Autor(en) / Beteiligte

• Caini, Saverio
• Casalegno, Jean-Sebastien
• Rodrigues, Ana Paula
• Lee, Vernon
• Cohen, Cheryl
• Huang, Q.Sue
• Bruno Caicedo, Alfredo
• Teirlinck, Anne
• Guiomar, Raquel
• Ang, Li Wei
• Moyes, Jocelyn
• Wood, Tim
• de Mora, Doménica
• Bangert, Mathieu
• Kramer, Rolf
• Staadegaard, Lisa
• Heemskerk, Susanne
• van Summeren, Jojanneke
• Meijer, Adam
• Paget, John

Titel

Change in Age profile of Respiratory Syncytial Virus disease over the course of annual epidemics: a multi-national study

Ist Teil von

• The Journal of infection, 2024-05, Vol.88 (5), p.106154-106154, Article 106154

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• We aimed to study whether the percentwise age distribution of RSV cases changes over time during annual epidemics. We used surveillance data (2008–2019) from the Netherlands, Lyon (France), Portugal, Singapore, Ecuador, South Africa, and New Zealand. In each country, every season was divided into “epidemic quarters”, i.e. periods corresponding to each quartile of RSV cases. Multinomial logistic regression models were fitted to evaluate whether the likelihood of RSV cases being aged <1 or ≥5 years (vs. 1 to <5) changed over time within a season. In all countries, RSV cases were significantly more likely to be aged <1 year in the 4th vs. 1st epidemic quarter; the relative risk ratio [RRR] ranged between 1.35 and 2.56. Likewise, RSV cases were significantly more likely to be aged ≥5 years in the 4th vs. 1st epidemic quarter (except in Singapore); the RRR ranged from 1.75 to 6.70. The results did not change when stratifying by level of care or moving the lower cut-off to 6 months. The age profile of RSV cases shifts within a season, with infants and adolescents, adults, and the elderly constituting a higher proportion of cases in the later phases of annual epidemics. These findings may have implications for RSV prevention policies with newly approved vaccines. •We studied whether the age of RSV cases changes over time during annual epidemics.•We used surveillance data (2008–2019) from seven countries around the world.•RSV cases become more likely to be aged <1 or >5 years as the epidemics unfolds.•The trend is largely consistent across countries and robust to sensitivity analyses.