Details

Autor(en) / Beteiligte

• Geffen, Eline G.M. van
• Nederend, Joost
• Sluckin, Tania C.
• Hazen, Sanne-Marije J.A.
• Aalbers, Arend G.J.
• van Aalten, Susanna M.
• Amelung, Femke J.
• Ashruf, Jesse F.
• Bakers, Frans C.H.
• Barendse, Renée M.
• Beets, Geerard L.
• Blok, Robin D.
• van Bockel, Liselotte W.
• den Boer, Frank C.
• Boogerd, Leonora S.F.
• Borstlap, Wernard A.A.
• Bouwman, Johanna E.
• Bradshaw, Jennifer
• Burger, Jacobus W.A.
• Cnossen, Jeltsje S.
• Coebergh van den Braak, Robert R.J.
• Corver, Maaike
• Crolla, Rogier M.P.H.
• Daniëls-Gooszen, Alette W.
• Demirkiran, Ahmet
• Derksen, Tyche
• van Dop, Ilse M.
• Droogh-de Greve, Kitty E.
• Dunker, Michalda S.
• Duyck, Johan
• van Duyn, Eino B.
• van Egdom, Laurentine S.E.
• Eijlers, Bram
• van Erp, Anne C.
• van Essen, Jeroen A.
• Fabry, Hans F.J.
• Feitsma, Eline A.
• Frietman, Bas
• van Geel, Anne M.
• Govaert, Marc J.P.M.
• de Haas, Robbert J.
• den Hartogh, Mariska D.
• Hogewoning, Cornelis R.C.
• van der Hul, René L.
• van Hulst, Rieke
• Imani, Farshad
• Keizers, Bas
• Kortekaas, Robert T.J.
• Lahuis, Derk H.H.
• Martens, MilouH
• Meijnen, Philip
• Muller, Karin
• Musters, Gijsbert D.
• de Nes, Lindsey C.F.
• Nonner, Joost
• Noordman, Bo J.
• Nordkamp, Stefi
• Olthof, Pim B.
• Oosterling, Steven J.
• Ootes, Daan
• Oppedijk, Vera
• Peeters, Koen C.M.J.
• Pereboom, Ilona T.A.
• Peringa, Jan
• Polat, Fatih
• Renger, Rutger-Jan
• Rombouts, Anouk J.M.
• Roskott-ten Brinke, Ellen A.
• Rouw, Dennis B.
• Rozema, Tom
• Schasfoort, Renske A.
• Scheurkogel, Merel M.
• Schuivens, Puck M.E.
• Slob, Marjan J.
• van der Sluis, Martsje
• Smalbroek, Bo P.
• Tielbeek, Jeroen A.W.
• van Tilborg, Fiek
• van Trier, Dorothée
• van der Valk, Maxime J.M.
• Vanhooymissen, Inge J.S.
• Vasbinder, G. Boudewijn C.
• Velema, Laura A.
• Verduin, Wouter M.
• Verhagen, Tim
• Verrijssen, An-Sofie E.
• Vliegen, Roy F.A.
• Voets, Sophie
• de Vries, Marianne
• van Vugt, Bas S.T.
• Wegdam, Johannes A.
• van Wely, Bob J.
• Westerterp, Marinke
• Woensdregt, Karlijn
• van der Wolk, Sander
• Zamaray, Bobby
• Zandvoort, Herman J.A.
• Zheng, Kang J.
• Zimmerman, David D.E.
• Zorgdrager, Marcel

Titel

Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment

Ist Teil von

• European journal of surgical oncology, 2024-06, Vol.50 (6), p.108307-108307, Article 108307

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Detection of grade 3–4 extra mural venous invasion (mrEMVI) on magnetic resonance imaging (MRI) is associated with an increased distant metastases (DM)-rate. This study aimed to determine the impact of different grades of mrEMVI and their disappearance after neoadjuvant therapy. A Dutch national retrospective cross-sectional study was conducted, including patients who underwent resection for rectal cancer in 2016 from 60/69 hospitals performing rectal surgery. Patients with a cT3-4 tumour ≤8 cm from the anorectal junction were selected and their MRI-scans were reassessed by trained abdominal radiologists. Positive mrEMVI grades (3 and 4) were analyzed in regard to 4-year local recurrence (LR), DM, disease-free survival (DFS) and overall survival (OS). The 1213 included patients had a median follow-up of 48 months (IQR 30–54). Positive mrEMVI was present in 324 patients (27%); 161 had grade 3 and 163 had grade 4. A higher mrEMVI stage (grade 4 vs grade 3 vs no mrEMVI) increased LR-risk (21% vs 18% vs 7%, <0.001) and DM-risk (49% vs 30% vs 21%, p < 0.001) and decreased DFS (42% vs 55% vs 69%, p < 0.001) and OS (62% vs 76% vs 81%, p < 0.001), which remained independently associated in multivariable analysis. When mrEMVI had disappeared on restaging MRI, DM-rate was comparable to initial absence of mrEMVI (both 26%), whereas LR-rate remained high (22% vs 9%, p = 0.006). The negative oncological impact of mrEMVI on recurrence and survival rates was dependent on grading. Disappearance of mrEMVI on restaging MRI decreased the risk of DM, but not of LR.