Details

Autor(en) / Beteiligte

• Chen, Yuan-Hsin
• Wei, Chih-Fu
• Cheng, Ya-Yun
• Mita, Carol
• Hoang, Chinh Lu Duc
• Lin, Cheng-Kuan
• Chang, Yu-Tzu
• Christiani, David C.

Titel

Urine cadmium and urolithiasis: A systematic review and meta-analysis

Ist Teil von

• Environmental research, 2024-07, Vol.252 (Pt 1), p.118745-118745, Article 118745

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Exposure to cadmium may increase risk of urolithiasis, but the results remain inconclusive. This systematic review and meta-analysis aimed to access the association between cadmium exposure and urolithiasis. We searched Medline/PubMed, Embase, Web of Science Core Collection, and Cochrane Central for studies. The primary outcome was the incidence of urolithiasis compared to reference groups. We used relative risk as the summary effect measure. This meta-analysis included eight observational studies and divided into 39 study populations. Among 63,051 subjects, 5018 (7.96%) individuals had urolithiasis. The results indicated that people with an increment of 0.1 μg/g creatinine in urinary cadmium had a 2% increased risk of urolithiasis (pooled relative risk [RR], 1.02; 95% confidence interval [CI], 1.01–1.03) and there is no difference in the risk of urolithiasis in high and low cadmium exposure levels. Meanwhile, people with an increment of 0.1 μg/L in urinary cadmium had a 4% increased risk of urolithiasis (pooled RR, 1.04; 95% CI, 1.02–1.07). Our findings also showed similar associations in both sex, different region (Sweden, China, and Thailand), general and occupational population. The results indicate that cadmium exposure was significantly associated with an elevated risk of urolithiasis. Therefore, it is imperative to take steps to minimize cadmium exposure. •Higher urinary cadmium is associated with an increased incidental urolithiasis risk.•The association could be found in different genders, regions, and exposure settings.•Standardized rate ratio aids urolithiasis comparison in 39 unique study populations.