Details

Autor(en) / Beteiligte

• YE, Qiao
• HUO, Jia Nan
• LUO, Yuan
• MEI, Zhu Song
• FANG, Long Mei
• GUO, Bing Qian
• WANG, Guang Yun

Titel

Sodium Sulfite as a Novel Hypoxia Revulsant Involved in Hypoxic Regulation in Escherichia coli

Ist Teil von

• Biomedical and environmental sciences, 2024-02, Vol.37 (2), p.228-232

Ort / Verlag

China: Elsevier B.V

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• As a reducing salt, sodium sulfite could deprive oxygen in solution, which could mimic hypoxic stress in . In this study, the wild-type strain MG1655 was used to examine the inhibition of sodium sulfite-induced hypoxia by observing the bacterial growth curves. We also analyzed the growth curves of mutant strains (for , , , and ) related to hypoxic pathways to reveal roles of the related genes during hypoxia. The ultrastructure of hypoxia-inhibited bacteria were also observed using transmission electron microscopy. Sodium sulfite could maintain hypoxic condition of bacterial culture for 8 h with concentrations over 40 mmol/L. Complete ultrastructure of the bacteria indicated sodium sulfite did inhibit bacterial growth and division. Among the hypoxia genes, and played key roles in sodium sulfite-induced hypoxia. This study showed that sodium sulfite could be used as a novel hypoxia revulsant for bacterial cultures.