Details

Autor(en) / Beteiligte

• Li, Xiaowei
• Young, Emma R.
• Martin, Cameron
• Ribaudo, Joseph G.
• Zaghloul, Mohamed
• Roberts, Sophia
• Meade, Rodrigo
• Arif, Batool
• Moritz, William R.
• Madira, Sarah
• Schofield, Jonathon B.
• Xun, Helen
• Hicks, Caitlin W.
• Kang, Sung H.
• Zayed, Mohamed A.
• Sacks, Justin M.

Titel

Vaso-Lock for sutureless anastomosis in a pig arteriovenous loop model

Ist Teil von

• Biomaterials, 2024-07, Vol.308, p.122563-122563, Article 122563

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A vascular anastomosis is a critical surgical skill that involves connecting blood vessels. Traditional handsewn techniques can be challenging and resource intensive. To address these issues, we have developed a unique sutureless anastomotic device called Vaso-Lock. This intraluminal device connects free vascular ends using anchors to maintain traction and enable a rapid anastomosis. We tested the anastomotic capability of Vaso-Locks in a pig common carotid-internal jugular arteriovenous model. The use of Vaso-Lock allowed us to accomplish this procedure in less than 10 min, in contrast to the approximately 40 min required for a handsewn anastomosis. The Vaso-Lock effectively maintained patency for at least 6 weeks without causing significant tissue damage. Histological analysis revealed that the device was successfully incorporated into the arterial wall, promoting a natural healing process. Additionally, organ evaluations indicated no adverse effects from using the Vaso-Lock. Our findings support the safety and effectiveness of the Vaso-Lock for arteriovenous anastomosis in pigs, with potential applicability for translation to humans. Our novel sutureless device has the potential to advance surgical practice and improve patient outcomes.