Details

Autor(en) / Beteiligte

• Petersen, Max C.
• Smith, Gordon I.
• Palacios, Hector H.
• Farabi, Sarah S.
• Yoshino, Mihoko
• Yoshino, Jun
• Cho, Kevin
• Davila-Roman, Victor G.
• Shankaran, Mahalakshmi
• Barve, Ruteja A.
• Yu, Jinsheng
• Stern, Jennifer H.
• Patterson, Bruce W.
• Hellerstein, Marc K.
• Shulman, Gerald I.
• Patti, Gary J.
• Klein, Samuel

Titel

Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity

Ist Teil von

• Cell metabolism, 2024-04, Vol.36 (4), p.745-761.e5

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• There is considerable heterogeneity in the cardiometabolic abnormalities associated with obesity. We evaluated multi-organ system metabolic function in 20 adults with metabolically healthy obesity (MHO; normal fasting glucose and triglycerides, oral glucose tolerance, intrahepatic triglyceride content, and whole-body insulin sensitivity), 20 adults with metabolically unhealthy obesity (MUO; prediabetes, hepatic steatosis, and whole-body insulin resistance), and 15 adults who were metabolically healthy lean. Compared with MUO, people with MHO had (1) altered skeletal muscle biology (decreased ceramide content and increased expression of genes involved in BCAA catabolism and mitochondrial structure/function); (2) altered adipose tissue biology (decreased expression of genes involved in inflammation and extracellular matrix remodeling and increased expression of genes involved in lipogenesis); (3) lower 24-h plasma glucose, insulin, non-esterified fatty acids, and triglycerides; (4) higher plasma adiponectin and lower plasma PAI-1 concentrations; and (5) decreased oxidative stress. These findings provide a framework of potential mechanisms responsible for MHO and the metabolic heterogeneity of obesity. This study was registered at ClinicalTrials.gov (NCT02706262). [Display omitted] •There is marked heterogeneity in metabolic abnormalities associated with obesity•Some people are resistant to adverse metabolic effects of excess adiposity•Differences involve multi-organ system function and adipose tissue/muscle biology Some people with obesity are resistant to the adverse cardiometabolic effects of excess adiposity and are considered to have “metabolically healthy obesity.” Petersen et al. evaluated 100 cardiometabolic outcomes and gene expression in adipose tissue and skeletal muscle to construct a comprehensive physiological atlas of metabolically healthy and unhealthy obesity.