Details

Autor(en) / Beteiligte

• Oh, Phil-Sun
• Han, Yeon-Hee
• Lim, SeokTae
• Vetha, Berwin Singh Swami
• Jeong, Hwan-Jeong

Titel

Antiviral and synergistic effects of photo-energy with acyclovir on herpes simplex virus type 1 infection

Ist Teil von

• Virology (New York, N.Y.), 2024-07, Vol.595, p.110063-110063, Article 110063

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• This experimental study aimed to evaluate the antiviral and synergistic effects of photoenergy irradiation on human herpes simplex virus type I (HSV-1) infection. We assessed viral replication, plaque formation, and relevant viral gene expression to examine the antiviral and synergistic effects of blue light (BL) with acyclovir treatment. Our results showed that daily BL (10 J/cm2) irradiation inhibited plaque-forming ability and decreased viral copy numbers in HSV-1-infected monkey kidney epithelial Vero cells and primary human oral keratinocyte (HOK) cells. Combined treatment with the antiviral agent acyclovir and BL irradiation increased anti-viral activity, reducing viral titers and copy numbers. In particular, accumulated BL irradiation suppressed characteristic viral genes including UL19 and US6, and viral DNA replication-essential genes including UL9, UL30, UL42, and UL52 in HOK cells. Our results suggest that BL irradiation has anti-viral and synergistic properties, making it a promising therapeutic candidate for suppressing viral infections in clinical trials. •BL irradiation was not genotoxic or cytotoxic to Vero and CCD-1131Sk cells.•Accumulated-BL irradiation decreased plaque-forming activity and inhibited viral replication of HSV-1.•Combined treatment with the antiviral agent acyclovir and BL irradiation increased anti-viral activity.