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Nd1.85Ce0.15Cu1−xMnxO4 samples with doping level up to 30% have been synthesized. The influence of Mn on crystal structure, superconductivity and normal-state magnetic properties of Nd1.85Ce0.15Cu1O4 (NCCO) is studied. Different from the doping effect in others high-Tc cuprates, Mn doping in NCCO causes an orthorhombic-to-tetragonal structure transition, and significantly suppresses the superconductivity for both Tc and Meissner volume. The effective magnetic moment per lattice cell increases with increasing Mn content, resulting in an antiferromagnetic correlation at high doping levels and a complete destroy of superconductivity.