Details

Autor(en) / Beteiligte

• Shojo, Kazunori
• Takeda, Toshikazu
• Akita, Hirotaka
• Suzuki, Tatsuya
• Mikami, Shuji
• Shigeta, Keisuke
• Yasumizu, Yota
• Tanaka, Nobuyuki
• Matsumoto, Kazuhiro
• Morita, Shinya
• Kosaka, Takeo
• Mizuno, Ryuichi
• Asanuma, Hiroshi
• Jinzaki, Masahiro
• Oya, Mototsugu

Titel

Prediction of pathological up-staging after radical nephroureterectomy in patients with upper tract urothelial carcinoma

Ist Teil von

• World journal of urology, 2024-03, Vol.42 (1), p.192-192, Article 192

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose The diagnostic accuracy of computed tomography urography for upper tract urothelial carcinoma is high; however, difficulties are associated with precisely assessing the T stage. Preoperative tumor staging has an impact on treatment options for upper tract urothelial carcinoma. We herein attempted to identify preoperative factors that predict pathological tumor up-staging, which will facilitate the selection of treatment strategies. Materials and methods We retrospectively identified 148 patients with upper tract urothelial carcinoma who underwent computed tomography urography preoperatively followed by radical nephroureterectomy without preoperative chemotherapy at our institution between 2000 and 2021. Preoperative factors associated with cT2 or lower to pT3 up-staging were examined using a multivariate logistic regression analysis. Results Ninety out of 148 patients were diagnosed with cT2 or lower, and 22 (24%) were up-staged to pT3. A multivariate analysis identified a positive voided urine cytology (HR 4.69, p = 0.023) and tumor length ≥ 3 cm (HR 6.33, p = 0.003) as independent predictors of pathological tumor up-staging. Conclusions Patients diagnosed with cT2 or lower, but with preoperative positive voided urine cytology and/or tumor diameter ≥ 3 cm need to be considered for treatment as cT3.