Details

Autor(en) / Beteiligte

• Antosyuk, Olga Nikolaevna
• Sharova, Elena Aleksandrovna
• Verbitskaya, Anastasiya Konstantinovna

Titel

Genetic activity and cytotoxic effect of Silybum marianum extract in comparison with the impact of antitumor drugs etoposide and methotrexate: a study on Drosophila melanogaster

Ist Teil von

• Natural product research, 2024-03, p.1-4

Ort / Verlag

England

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• One of the most important directions in medical practice involves the exploration of protectors and adaptogens to mitigate side effects associated with the use of antitumor and potent medications. The extracts of medicinal plants are actively tested as protectors. In connection with this, the aim of the research was to determine the effectiveness of the protective properties of extract against the drugs 'etoposide' and 'methotrexate' at concentrations of 800 μg/kg using the model object . To analyse the protective properties, the following research methods were applied: determining the lethal concentration, average individual fertility of individuals, mortality of F offspring at embryonic stages, SMART (a method for determining the frequency of somatic mutations and recombinations) and assessing the intensity of programmed cell death. The study revealed that a 5% extract reduces the genotoxicity of etoposide and exhibits a high cytotoxic effect, both independently and in combination with etoposide and methotrexate.