Details

Autor(en) / Beteiligte

• Gong, Changtian
• Yang, Jian
• Zhang, Xiping
• Wang, Xingyu
• Wei, Zicheng
• Huang, Xinghan
• Guo, Weichun

Titel

Surface functionalization of calcium magnesium phosphate cements with alginate sodium for enhanced bone regeneration via TRPM7/PI3K/Akt signaling pathway

Ist Teil von

• International journal of biological macromolecules, 2024-05, Vol.266 (Pt 1), p.130998-130998, Article 130998

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Although calcium‑magnesium phosphate cements (CMPCs) have been widely applied to treating critical-size bone defects, their repair efficiency is unsatisfactory owing to their weak surface bioactivity and uncontrolled ion release. In this study, we lyophilized alginate sodium (AS) as a coating onto HAp/K-struvite (H@KSv) to develop AS/HAp/K-struvite (AH@KSv), which promotes bone regeneration. The compressive strength and hydrophilicity of AH@KSv significantly improved, leading to enhanced cell adhesion in vitro. Importantly, the SA coating enables continuous ions release of Mg2+ and Ca2+, finally leading to enhanced osteogenesis in vitro/vivo and different patterns of new bone ingrowth in vivo. Furthermore, these composites increased the expression levels of biomarkers of the TRPM7/PI3K/Akt signaling pathway via an equilibrium effect of Mg2+ to Ca2+. In conclusion, our study provides novel insights into the mechanisms of Mg-based biomaterials for bone regeneration. •Novel scaffold (AH@KSv) with improved surface bioactivity were successfully prepared via the lyophilization method.•AH@KSv enhances in vitro/in vivo osteogenesis in bone regeneration.•Regulatory mechanisms of TRPM7/PI3K/Akt signaling pathway are related to equilibrium effect of Mg2+ to Ca2+.