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Laboratory characterization of the pediatric B/T subtype of mixed-phenotype acute leukemia: Report of a case series
Ist Teil von
American journal of clinical pathology, 2024-08, Vol.162 (2), p.180-190
Ort / Verlag
England
Erscheinungsjahr
2024
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
Mixed-phenotype acute leukemia (MPAL) is a rare disease associated with difficulties in the correct lineage assignment of leukemic cells. One of the least common subtypes within this category is characterized by the simultaneous presence of B- and T-lineage-defining antigens. Each case of suspected B/T MPAL should be considered in light of all available laboratory and clinical data to avoid misdiagnosis.
In this study, we describe 6 pediatric patients who presented with leukemic blasts bearing B- and T-lineage antigens at diagnosis, including their clinical, immunophenotypic, morphologic, and cytogenetic characteristics.
In 3 patients, more or less distinct populations of B- and T-lymphoid origin were found; the other 3 patients had a single mixed-phenotype blast population. All cases fulfilled the World Health Organization criteria, but not all of them turned out to be bona fide cases of B/T MPAL according to the available clinical and laboratory data. Found genetic lesions were helpful for the confirmation of MPAL instead of 2 concomitant tumors, but for a general B/T MPAL diagnosis, genetic studies provided the only descriptive data.
The accurate diagnosis of B/T MPAL requires a multidisciplinary approach combining high-tech laboratory methods and close cooperation between treating physicians and pathologists.
Sprache
Englisch
Identifikatoren
ISSN: 0002-9173, 1943-7722
eISSN: 1943-7722
DOI: 10.1093/ajcp/aqae020
Titel-ID: cdi_proquest_miscellaneous_2974005952
Format
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