Details

Autor(en) / Beteiligte

• Demina, Irina
• Mikhailova, Ekaterina
• Zerkalenkova, Elena
• Semchenkova, Alexandra
• Roumiantseva, Julia
• Borkovskaya, Alexandra
• Matveev, Evgeny
• Abramov, Dmitry
• Konovalov, Dmitry
• Miakova, Natalia
• Ponomareva, Natalia
• Belkina, Julia
• Kondratchik, Konstantin
• Olshanskaya, Yulia
• Novichkova, Galina
• Karachunskiy, Alexander
• Popov, Alexander

Titel

Laboratory characterization of the pediatric B/T subtype of mixed-phenotype acute leukemia: Report of a case series

Ist Teil von

• American journal of clinical pathology, 2024-08, Vol.162 (2), p.180-190

Ort / Verlag

England

Erscheinungsjahr

2024

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Mixed-phenotype acute leukemia (MPAL) is a rare disease associated with difficulties in the correct lineage assignment of leukemic cells. One of the least common subtypes within this category is characterized by the simultaneous presence of B- and T-lineage-defining antigens. Each case of suspected B/T MPAL should be considered in light of all available laboratory and clinical data to avoid misdiagnosis. In this study, we describe 6 pediatric patients who presented with leukemic blasts bearing B- and T-lineage antigens at diagnosis, including their clinical, immunophenotypic, morphologic, and cytogenetic characteristics. In 3 patients, more or less distinct populations of B- and T-lymphoid origin were found; the other 3 patients had a single mixed-phenotype blast population. All cases fulfilled the World Health Organization criteria, but not all of them turned out to be bona fide cases of B/T MPAL according to the available clinical and laboratory data. Found genetic lesions were helpful for the confirmation of MPAL instead of 2 concomitant tumors, but for a general B/T MPAL diagnosis, genetic studies provided the only descriptive data. The accurate diagnosis of B/T MPAL requires a multidisciplinary approach combining high-tech laboratory methods and close cooperation between treating physicians and pathologists.