Details

Autor(en) / Beteiligte

• Dine, Elliot
• Youle, Richard J.

Titel

Integrating the response to stressed mitochondria

Ist Teil von

• Molecular cell, 2024-03, Vol.84 (6), p.995-997

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Chakrabarty et al.1 demonstrate that phospho-EIF2α (pEIF2α), the translation initiation factor that mediates the integrated stress response (ISR), is necessary and sufficient for the autophagic degradation of mitochondria following the addition of mitochondrial stressors. Chakrabarty et al. demonstrate that phospho-EIF2α (pEIF2α), the translation initiation factor that mediates the integrated stress response (ISR), is necessary and sufficient for the autophagic degradation of mitochondria following the addition of mitochondrial stressors.