Chemistry & biodiversity, 2024-05, Vol.21 (5), p.e202400090-n/a
2024
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- Autor(en) / Beteiligte
- Titel
- New Analogues of Amides and Quinolinones Produced by Streptomyces sp. YIM S01983
- Ist Teil von
- Chemistry & biodiversity, 2024-05, Vol.21 (5), p.e202400090-n/a
- Ort / Verlag
- Switzerland: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2024
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Streptomide (1), a new amide analogue, streptomynone (2), a new quinolinone, and ten known compounds including three aliphatic acids (3‐5), two amides (6‐7), four cyclic dipeptides (8‐11), and an adenosine (12) were isolated from the fermentation broth of Streptomyces sp. YIM S01983 isolated from a sediment sample collected in Bendong Village, Huadong Town, Chuxiong, China. Their structures were determined by analysis of the 1D/2D‐NMR and HR‐ESI‐MS spectra. Compound 12 presented weak antimicrobial activities against Candida albicans and Aligenes faecalis (MIC=64 μg/mL). Compounds 7 and 12 showed weak cytotoxic activity against MHCC97H.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1612-1872eISSN: 1612-1880DOI: 10.1002/cbdv.202400090Titel-ID: cdi_proquest_miscellaneous_2958301188
- Format
- –
- Schlagworte
- Adenosine, Amides, Amides - chemistry, Amides - isolation & purification, Amides - pharmacology, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - isolation & purification, Anti-Bacterial Agents - pharmacology, Antifungal Agents - chemistry, Antifungal Agents - isolation & purification, Antifungal Agents - pharmacology, antimicrobial activity, Antineoplastic Agents - chemistry, Antineoplastic Agents - isolation & purification, Antineoplastic Agents - pharmacology, antitumor activity, Candida albicans - drug effects, Cell Line, Tumor, Cyclic dipeptides, Cytotoxicity, Disease resistance, Drug Screening Assays, Antitumor, Enterococcus faecalis - drug effects, Fermentation, Humans, Microbial Sensitivity Tests, Molecular Structure, NMR, Nuclear magnetic resonance, Quinolones - chemistry, Quinolones - isolation & purification, Quinolones - pharmacology, secondary metabolites, Sediment samplers, Sediment samples, Streptomyces, Streptomyces - chemistry, Streptomyces - metabolism, Streptomyces sp. YIM S01983, Structure-Activity Relationship, Two dimensional analysis