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Pseudomembranous colitis and Parabacteroides distasonis bacteraemia: a rare clinical presentation
Ist Teil von
Clinical journal of gastroenterology, 2024-06, Vol.17 (3), p.457-460
Ort / Verlag
Singapore: Springer Nature Singapore
Erscheinungsjahr
2024
Link zum Volltext
Quelle
Springer Online Journals【Remote access available】
Beschreibungen/Notizen
We present the case of a male with end-stage diabetic nephropathy on haemodialysis who initially presented with acute-on-chronic digital ulceration. While awaiting vascular intervention, he became septic with abdominal pain and diarrhoea. Flexible sigmoidoscopy confirmed pseudomembranous colitis secondary to
Clostridium difficile
. Blood cultures grew
Parabacteroides distasonis
, a Gram-negative gut anaerobe.
Enterobacter cloacae
, another Gram-negative anaerobic gut bacilli, was grown in colonic cultures and swabs of the digital ulcers. We hypothesise that the pseudomembranous colitis increased gut translocation and thus led to the systemic spread of both gut anaerobes. This is the first reported case of
Parabacteroides distasonis
bacteraemia in the context of
Clostridium difficile
infection. Our patient recovered with antibiotics and went on to have vascular intervention for his digital ulceration.