Details

Autor(en) / Beteiligte

• Duque, Laura
• Ghafouri, Mohammad
• Nunez, Nicolas A.
• Ospina, Juan Pablo
• Philbrick, Kemuel L.
• Port, John D.
• Savica, Rodolfo
• Prokop, Larry J.
• Rummans, Teresa A.
• Singh, Balwinder

Titel

Functional neuroimaging in patients with catatonia: A systematic review

Ist Teil von

• Journal of psychosomatic research, 2024-04, Vol.179, p.111640-111640, Article 111640

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Catatonia is a challenging and heterogeneous neuropsychiatric syndrome of motor, affective and behavioral dysregulation which has been associated with multiple disorders such as structural brain lesions, systemic diseases, and psychiatric disorders. This systematic review summarized and compared functional neuroimaging abnormalities in catatonia associated with psychiatric and medical conditions. Using PRISMA methods, we completed a systematic review of 6 databases from inception to February 7th, 2024 of patients with catatonia that had functional neuroimaging performed. A total of 309 studies were identified through the systematic search and 62 met the criteria for full-text review. A total of 15 studies reported patients with catatonia associated with a psychiatric disorder (n = 241) and one study reported catatonia associated with another medical condition, involving patients with N-methyl-d-aspartate receptor antibody encephalitis (n = 23). Findings varied across disorders, with hyperactivity observed in areas like the prefrontal cortex (PFC), the supplementary motor area (SMA) and the ventral pre-motor cortex in acute catatonia associated to a psychiatric disorder, hypoactivity in PFC, the parietal cortex, and the SMA in catatonia associated to a medical condition, and mixed metabolic activity in the study on catatonia linked to a medical condition. Findings support the theory of dysfunction in cortico-striatal-thalamic, cortico-cerebellar, anterior cingulate-medial orbitofrontal, and lateral orbitofrontal networks in catatonia. However, the majority of the literature focuses on schizophrenia spectrum disorders, leaving the pathophysiologic characteristics of catatonia in other disorders less understood. This review highlights the need for further research to elucidate the pathophysiology of catatonia across various disorders. •Catatonia is associated with multiple illnesses beyond psychiatric disorders.•Functional neuroimaging findings indicate multiple circuits dysfunction.•Most of functional neuroimaging research in catatonia has focused on schizophrenia.•Catatonia in medical and psychiatric disorders may show distinct dysfunction patterns.