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Striatal and Extrastriatal Monoaminergic Disruption in Progressive Supranuclear Palsy
Movement disorders, 2024-05, Vol.39 (5), p.847-854
Ma, Jing‐Hong
Dong, Chong
Qiao, Hong‐Wen
Barret, Olivier
Tamagnan, Gilles D.
Mao, Wei
Xu, Er‐He
Zhang, Chun
Lu, Jie
Chan, Piu
Liu, Shu‐Ying
2024
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Ma, Jing‐Hong
Dong, Chong
Qiao, Hong‐Wen
Barret, Olivier
Tamagnan, Gilles D.
Mao, Wei
Xu, Er‐He
Zhang, Chun
Lu, Jie
Chan, Piu
Liu, Shu‐Ying
Titel
Striatal and Extrastriatal Monoaminergic Disruption in Progressive Supranuclear Palsy
Ist Teil von
Movement disorders, 2024-05, Vol.39 (5), p.847-854
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2024
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Background As a biomarker targeting vesicular monoamine transporter 2 (VMAT2), 18F‐9‐fluoropropyldihydrotetrabenazine (18F‐FP‐DTBZ) positron emission tomography (PET) is highly accurate in diagnosing Parkinson's disease (PD) and assessing its severity. However, evidence is insufficient in patients with progressive supranuclear palsy (PSP). Objective We evaluated the striatal and extrastriatal monoaminergic disruption of PSP and differences in patterns between patients with PSP, PD, and healthy controls (HCs) using 18F‐FP‐DTBZ PET, as well as its correlations with the clinical characteristics of PSP. Methods We recruited 58 patients with PSP, 23 age‐ and duration‐matched patients with PD, as well as 17 HCs. Patients were scanned using 18F‐FP‐DTBZ PET/computed tomography, and images were spatially normalized and analyzed based on the volume of interest. Results VMAT2 binding differed significantly in the striatum and substantia nigra among the groups (P < 0.001). A more severe disruption in the caudate was noted in the PSP group (P < 0.001) than in the PD group. However, no differences were found in the nucleus accumbens, hippocampus, amygdala, or raphe between the PD and PSP groups. Within the PSP group, striatal VMAT2 binding was significantly associated with the fall/postural stability subscore of the PSP Rating Scale, especially in the putamen. Furthermore, VMAT2 binding was correlated with Mini‐Mental State Examination or Montreal Cognitive Assessment in the hippocampus. Conclusions Caudate disruptions showed prominent differences among the groups. VAMT2 binding in the striatum and hippocampus reflects the severity of fall/postural stability and cognition, respectively. © 2024 International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.29769
Titel-ID: cdi_proquest_miscellaneous_2956681203
Format
–
Schlagworte
Aged
,
Amygdala
,
Computed tomography
,
Corpus Striatum - diagnostic imaging
,
Corpus Striatum - metabolism
,
Female
,
Hippocampus
,
Humans
,
Male
,
Middle Aged
,
monoamine
,
motor symptom
,
Movement disorders
,
Neostriatum
,
Neurodegenerative diseases
,
Nucleus accumbens
,
Parkinson Disease - diagnostic imaging
,
Parkinson Disease - metabolism
,
Parkinson's disease
,
Positron emission tomography
,
Positron Emission Tomography Computed Tomography - methods
,
Positron-Emission Tomography - methods
,
Posture
,
Progressive supranuclear palsy
,
Putamen
,
Substantia nigra
,
Substantia Nigra - diagnostic imaging
,
Substantia Nigra - metabolism
,
Substantia Nigra - pathology
,
Supranuclear Palsy, Progressive - diagnostic imaging
,
Supranuclear Palsy, Progressive - metabolism
,
Tetrabenazine - analogs & derivatives
,
Tomography
,
Vesicular Monoamine Transport Proteins - metabolism
,
Vesicular monoamine transporter
,
Vesicular monoamine transporter 2
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