Details

Autor(en) / Beteiligte

• Larbi, Imen
• Arbi, Marwa
• Souiai, Oussama
• Tougorti, Halima
• Butcher, Gary David
• Nsiri, Jihene
• Badr, Chaima
• Behi, Imen EL
• Lachhab, Jihene
• Ghram, Abdeljelil

Titel

Phylogeographic Dynamics of H9N2 Avian Influenza Viruses in Tunisia

Ist Teil von

• Virus research, 2024-06, Vol.344, p.199348-199348, Article 199348

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Genetic evolution of H9N2 avian influenza virus in Tunisia that has been isolated from chicken, is characterized by molecular markers implicated in virulence and mammalian infections.•Based on genomic sequences of H9N2, the construction of phylogeogrphic network shed light on new transmission routes of virus, not described previously, involving countries from Maghreb region notably Algeria and Morocco.•Spatiotemporal dynamics revealed exchanges between Tunisian H9N2 viruses and those of the Middle Eastern countries.•Viruses from Duck, wild birds and environment rise from a common ancestor ‘chicken’.•Phylodynamic analysis revealed that PB2 segment was undergone an inter-subtype reassortment events. Avian influenza virus subtype H9N2 is endemic in commercial poultry in Tunisia. This subtype affects poultry and wild birds in Tunisia and poses a potential zoonotic risk. Tunisian H9N2 strains carry, in their hemagglutinins, the human-like marker 226 L that is most influential in avian-to-human viral transmission. For a better understanding of how ecological aspects of the H9N2 virus and its circulation in poultry, migratory birds and environment shapes the spread of the dissemination of H9N2 in Tunisia, herein, we investigate the epidemiological, evolutionary and zoonotic potential of seven H9N2 poultry isolates and sequence their whole genome. Phylogeographic and phylodymanic analysis were used to examine viral spread within and among wild birds, poultry and environment at geographical scales. Genetic evolution results showed that the eight gene sequences of Tunisian H9N2 AIV were characterized by molecular markers involved with virulence and mammalian infections. The geographical distribution of avian influenza virus appears as a network interconnecting countries in Europe, Asia, North Africa and West Africa. The spatiotemporal dynamics analysis showed that the H9N2 virus was transmitted from Tunisia to neighboring countries notably Libya and Algeria. Interestingly, this study also revealed, for the first time, that there was a virus transmission between Tunisia and Morocco. Bayesian analysis showed exchanges between H9N2 strains of Tunisia and those of the Middle Eastern countries, analysis of host traits showed that duck, wild birds and environment were ancestry related to chicken. The subtypes phylodynamic showed that PB1 segment was under multiple inter-subtype reassortment events with H10N7, H12N5, H5N2 and H6N1 and that PB2 was also a subject of inter-subtype reassortment with H10N4.