Details

Autor(en) / Beteiligte

• Vāvere, Amy L.
• Ghosh, Arijit
• Amador Diaz, Victor
• Clay, Allison J.
• Hall, Peter M.
• Neumann, Kiel D.

Titel

Automated radiosynthesis of [18F]DPA-714 on a commercially available IBA Synthera

Ist Teil von

• Applied radiation and isotopes, 2024-05, Vol.207, p.111257-111257, Article 111257

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The goal of this work was to develop a reliable method to produce the well-validated microglial activation PET tracer, [18F]DPA-714, routinely for clinical and preclinical research using an IBA Synthera®. Optimization of literature methods included reduced precursor mass and use of TBA HCO3 as the phase transfer agent in place of Kryptofix® 222 in a 65-min synthesis with an average activity yield of 24.6 ± 3.8% (n = 5). Successful quality control testing and process validation results are reported. •An IND-approved method for production of [18F]DPA-714 on an IBA Synthera® is reported.•Reduction of precursor mass and replacement of Kryptofix® 222 as phase transfer agent support production of tracer in reliable quantities for clinical research.•Justification of 5% injected ethanol in pediatric PET tracer preparations was outlined.