Details

Autor(en) / Beteiligte

• de Graaff, Michelle R.
• Klaase, Joost M.
• den Dulk, Marcel
• te Riele, Wouter W.
• Hagendoorn, Jeroen
• van Heek, N. Tjarda
• Vermaas, M.
• Belt, Eric J. Th
• Bosscha, Koop
• Slooter, Gerrit D.
• Leclercq, Wouter K.G.
• Liem, Mike S.L.
• Mieog, J. Sven D.
• Swijnenburg, Rutger-Jan
• van Dam, Ronald M.
• Verhoef, Cees
• Kuhlmann, Koert
• van Duijvendijk, Peter
• Gerhards, Michael F.
• Gobardhan, Paul
• van den Boezem, Peter
• Manusama, Eric R.
• Grünhagen, Dirk J.
• Kok, Niels F.M.
• Torrenga, Hans

Titel

Hospital variation and outcomes after repeat hepatic resection for colorectal liver metastases: a nationwide cohort study

Ist Teil von

• HPB (Oxford, England), 2024-06, Vol.26 (6), p.789-799

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Approximately 70% of patients with colorectal liver metastases (CRLM) experiences intrahepatic recurrence after initial liver resection. This study assessed outcomes and hospital variation in repeat liver resections (R-LR). This population-based study included all patients who underwent liver resection for CRLM between 2014 and 2022 in the Netherlands. Overall survival (OS) was collected for patients operated on between 2014 and 2018 by linkage to the insurance database. Data of 7479 liver resections (1391 (18.6%) repeat and 6088 (81.4%) primary) were analysed. Major morbidity and mortality were not different. Factors associated with major morbidity included ASA 3+, major liver resection, extrahepatic disease, and open surgery. Five-year OS after repeat versus primary liver resection was 42.3% versus 44.8%, P = 0.37. Factors associated with worse OS included largest CRLM >5 cm (aHR 1.58, 95% CI: 1.07–2.34, P = 0.023), >3 CRLM (aHR 1.33, 95% CI: 1.00–1.75, P = 0.046), extrahepatic disease (aHR 1.60, 95% CI: 1.25–2.04, P = 0.001), positive tumour margins (aHR 1.42, 95% CI: 1.09–1.85, P = 0.009). Significant hospital variation in performance of R-LR was observed, median 18.9% (8.2% to 33.3%). Significant hospital variation was observed in performance of R-LR in the Netherlands reflecting different treatment decisions upon recurrence. On a population-based level R-LR leads to satisfactory survival.