Details

Autor(en) / Beteiligte

• Tan, Lin
• Pan, Yang
• Zeng, Qing-Ying
• Wang, Zhen-Yu
• Xu, Hui
• Dai, Hui-Xiong

Titel

Palladium-Catalyzed Directed Carbon–Carbon Bond Activation of Aryl Nitriles for Cyano Transfer

Ist Teil von

• Organic letters, 2024-03, Vol.26 (11), p.2260-2265

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein, we report the C–H cyanation of indoles via a palladium-catalyzed directed C–CN activation reaction using aryl nitrile as a cyano source. The employment of the phenoxy-oriented group is the key to the cleavage of the C–CN bond. This protocol features a broad substrate scope, good efficiency, and high regioselectivity. Furthermore, the practical application of this protocol was showcased in the late-stage functionalization and synthesis of indole derivatives, which were derived from drugs and natural products, through the process of cyanation.