Details

Autor(en) / Beteiligte

• Yang, Li-Ting
• Wang, Wen-Jyun
• Huang, Wan-Ting
• Wang, Liu-Chun
• Hsu, Ming-Chien
• Kan, Chung-Dann
• Huang, Chun-Yung
• Wong, Tak-Wah
• Li, Wei-Peng

Titel

Photo-Responsive Ascorbic Acid-Modified Ag2S–ZnS Heteronanostructure Dropping pH to Trigger Synergistic Antibacterial and Bohr Effects for Accelerating Infected Wound Healing

Ist Teil von

• ACS applied materials & interfaces, 2024-03, Vol.16 (9), p.12018-12032

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nonantibiotic approaches must be developed to kill pathogenic bacteria and ensure that clinicians have a means to treat wounds that are infected by multidrug-resistant bacteria. This study prepared matchstick-like Ag2S–ZnS heteronanostructures (HNSs). Their hydrophobic surfactants were then replaced with hydrophilic poly­(ethylene glycol) (PEG) and thioglycolic acid (TGA) through the ligand exchange method, and this was followed by ascorbic acid (AA) conjugation with TGA through esterification, yielding well-dispersed PEGylated Ag2S–ZnS@TGA-AA HNSs. The ZnS component of the HNSs has innate semiconductivity, enabling the generation of electron–hole pairs upon irradiation with a light of wavelength 320 nm. These separate charges can react with oxygen and water around the HNSs to produce reactive oxygen species. Moreover, some holes can oxidize the surface-grafted AA to produce protons, decreasing the local pH and resulting in the corrosion of Ag2S, which releases silver ions. In evaluation tests, the PEGylated Ag2S–ZnS@TGA-AA had synergistic antibacterial ability and inhibited Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA). Additionally, MRSA-infected wounds treated with a single dose of PEGylated Ag2S–ZnS@TGA-AA HNSs under light exposure healed significantly more quickly than those not treated, a result attributable to the HNSs’ excellent antibacterial and Bohr effects.