Details

Autor(en) / Beteiligte

• Yamamoto, Kohei
• Shiotsu, Shinsuke
• Sasakura, Misaki
• Tanaka, Shunya
• Goda, Shiho
• Tsuji, Taisuke
• Yuba, Tatsuya
• Takumi, Chieko
• Hiraoka, Noriya

Titel

Cytokine Release Syndrome with Relative Adrenal Insufficiency Induced by Ipilimumab and Nivolumab Combination Therapy for Clear Cell Renal Cell Carcinoma

Ist Teil von

• Internal Medicine, 2024, pp.3115-23

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Combination therapy with ipilimumab and nivolumab is indicated for many types of cancers; however, several patients experience immune-related adverse events (irAEs). We herein report a case of cytokine release syndrome (CRS) in a 63-year-old woman with stage IV left clear cell renal cell carcinoma. Our patient developed CRS while taking prednisolone, 43 days after the start of ipilimumab and nivolumab administration. The patient was treated with steroid pulse therapy, which improved the symptoms of shock and respiratory failure. Increased vascular permeability and relative adrenal insufficiency are considered to be the main pathogeneses. The early administration of high-dose steroids is crucial as a replacement for corticosteroids.