Details

Autor(en) / Beteiligte

• Teng, Xifeng
• Shi, Huiwen
• Cao, Liudan
• Peng, Xing
• He, Lin
• Gu, Qiong

Titel

Chemical Constituents of Ajuga Lupulina and their Anti‐Ferroptosis Activity

Ist Teil von

• Chemistry & biodiversity, 2024-04, Vol.21 (4), p.e202400244-n/a

Ort / Verlag

Switzerland: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Five new compounds (1, 2, 7, 12, and 16), along with fifteen known ones, were isolated from Ajuga lupulina Maxim. Their structures were revealed by analysing spectroscopic data (MS, NMR), and experimental and calculated ECD spectra was used to deduce the absolute configuration. Compound 16, with eight carbon atoms, was firstly isolated from the nature. All the isolates were evaluated for their inhibitory effect on RSL3‐induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, the abietane‐type diterpenoids (7–11) significantly inhibited ferroptosis with EC50 values of 0.83 μM, 2.05 μM, 0.96 μM, 1.47 μM, and 1.19 μM, respectively.