Details

Autor(en) / Beteiligte

• Hu, Guanhua
• Sun, Xueying
• Hao, Shiqi
• Li, Xiaotong
• Qian, Min
• Dou, Lu
• Zhang, Min
• Hou, Puxin
• Su, Lin
• Zhao, Lihua
• Sun, Lina
• Jin, Ye

Titel

Effect of sheep bone protein hydrolysate on promoting calcium absorption and enhancing bone quality in low-calcium diet fed rats

Ist Teil von

• Food chemistry, 2024-07, Vol.446, p.138763-138763, Article 138763

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• [Display omitted] •SBPHs + CaCl2 treatment increased bone calcium levels and bone density.•SBPHs +CaCl2 treatment can change the bone turnover markers level in serum.•SBPHs+CaCl2 treatment can increase bone biomechanics and improve bone microarchitecture.•SBPHs+CaCl2 intervention alters the composition of the gut microbiota.•SBPHs+CaCl2 intervention promotes short-chain fatty acid production. Calcium deficiency is prone to fractures, osteoporosis and other symptoms. In this study, sheep bone protein hydrolysates (SBPHs) were obtained by protease hydrolysis. A low-calcium-diet-induced calcium-deficiency rat model was established to investigate the effects of SBPHs on calcium absorption and intestinal flora composition. The results showed that an SBPHs + CaCl2 treatment significantly increased the bone calcium content, bone mineral density, trabecular bone volume, and trabecular thickness, and reduced trabecular separation, and changed the level of bone turnover markers (P < 0.05). Supplementation of SBPHs + CaCl2 can remarkably enhance the bone mechanical strength, and the microstructure of bone was improved, and the trabecular network was more continuous, complete, and thicker. Additionally, SBPHs + CaCl2 dietary increased the abundance of Firmicutes and reduced the abundance of Proteobacteria and Verrucomicrobiota, and promoted the production of short chain fatty acids. This study indicated that SBPHs promoted calcium absorption and could be applied to alleviate osteoporosis.