Details

Autor(en) / Beteiligte

• Nene, Lindokuhle Cindy
• Abrahamse, Heidi

Titel

Phthalocyanine-based probes in alleviating or evading tumour-hypoxia for enhanced photo- and/ sono-mediated therapeutic efficacies

Ist Teil von

• Photodiagnosis and photodynamic therapy, 2024-04, Vol.46, p.104024-104024, Article 104024

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• •Strategies for designing phthalocyanine based anticancer probes for light and ultrasound stimulated therapies in hypoxic tumour environments.•Both light and ultrasound mediated therapies have shown promising anticancer activities, however, these techniques predominantly depend on the availability of oxygen.•Hypoxic tumours have limited oxygen, thus stunting the effectiveness of the treatments.•Techniques used to alleviate or evade hypoxia using phthalocyanine-based probes.•Design strategies that may be considered in the development of phthalocyanine-based agents for efficient cancer treatments under hypoxic conditions. This review discusses the possible methods for improving therapeutic efficacies of phthalocyanine (Pcs) -based therapeutic probes in photo- and sono-dynamic therapies under hypoxic conditions. Herein, the structural design strategies including varying the central metal, position substituents and the effects of adjuvant used in supplementing the therapeutics activities of Pcs or formation of NPs are discussed for cancer therapies in hypoxic conditions. Different mechanisms induced for cell death influenced by the compositions of the Pcs-probes are discussed. The focus mainly highlights the oxygen (O2) -dependent mechanisms including methods of supplementing tumour microenvironment O2-concentrations to promote PDT or SDT therapies. Alternatively, O2-independent mechanisms mainly used to evade hypoxia by stimulating anticancer processes that don't require O2 to initiate cell death, such as the Fenton reaction or thermal ablation effects.